Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus

A randomized controlled trial

Kentaro Wada, Yuko Wada, Haruhito Adam Uchida, Shuichi Tsuruoka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease – mineral and bone disorder in such patients. Methods: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. Results: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalInternational Journal of Nephrology and Renovascular Disease
Volume8
DOIs
Publication statusPublished - Aug 26 2015

Fingerprint

Vascular Stiffness
Calcium Carbonate
Type 2 Diabetes Mellitus
Minerals
Renal Dialysis
Randomized Controlled Trials
Bone and Bones
Pulse Wave Analysis
Ankle
Bone Density
Arm
Biomarkers
Chronic Kidney Disease-Mineral and Bone Disorder
Vascular Calcification
Osteocalcin
Alkaline Phosphatase
Cardiovascular Diseases
lanthanum carbonate

Keywords

  • Diabetes
  • Hemodialysis
  • Lanthanum carbonate
  • Randomized controlled trial
  • Vascular stiffness

ASJC Scopus subject areas

  • Nephrology

Cite this

@article{b6b3ddfb0ba54e92bdd5f7ace971a11e,
title = "Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus: A randomized controlled trial",
abstract = "Background: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease – mineral and bone disorder in such patients. Methods: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. Results: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P",
keywords = "Diabetes, Hemodialysis, Lanthanum carbonate, Randomized controlled trial, Vascular stiffness",
author = "Kentaro Wada and Yuko Wada and Uchida, {Haruhito Adam} and Shuichi Tsuruoka",
year = "2015",
month = "8",
day = "26",
doi = "10.2147/IJNRD.S90791",
language = "English",
volume = "8",
pages = "111--118",
journal = "International Journal of Nephrology and Renovascular Disease",
issn = "1178-7058",
publisher = "Dove Medical Press Limited",

}

TY - JOUR

T1 - Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus

T2 - A randomized controlled trial

AU - Wada, Kentaro

AU - Wada, Yuko

AU - Uchida, Haruhito Adam

AU - Tsuruoka, Shuichi

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Background: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease – mineral and bone disorder in such patients. Methods: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. Results: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P

AB - Background: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease – mineral and bone disorder in such patients. Methods: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. Results: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P

KW - Diabetes

KW - Hemodialysis

KW - Lanthanum carbonate

KW - Randomized controlled trial

KW - Vascular stiffness

UR - http://www.scopus.com/inward/record.url?scp=84940539669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940539669&partnerID=8YFLogxK

U2 - 10.2147/IJNRD.S90791

DO - 10.2147/IJNRD.S90791

M3 - Article

VL - 8

SP - 111

EP - 118

JO - International Journal of Nephrology and Renovascular Disease

JF - International Journal of Nephrology and Renovascular Disease

SN - 1178-7058

ER -