Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus: A randomized controlled trial

Kentaro Wada, Yuko Wada, Haruhito Adam Uchida, Shuichi Tsuruoka

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4 Citations (Scopus)

Abstract

Background: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease – mineral and bone disorder in such patients. Methods: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. Results: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalInternational Journal of Nephrology and Renovascular Disease
Volume8
DOIs
Publication statusPublished - Aug 26 2015

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Keywords

  • Diabetes
  • Hemodialysis
  • Lanthanum carbonate
  • Randomized controlled trial
  • Vascular stiffness

ASJC Scopus subject areas

  • Nephrology

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