Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high-cholesterol diet

Dong Mei Li, Da Yong Zhou, Bei Wei Zhu, Ya Li Chi, Li Ming Sun, Xiu Ping Dong, Lei Qin, Wei Zhou Qiao, Yoshiyuki Murata

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: In this study, whole krill oil (WKO) and phospholipid-type krill oil (PKO) with different lipid composition were prepared. The effects of KO intake on plasma cholesterol and glucose levels in Wistar rats fed a high-cholesterol diet (HCD) were investigated. Results: WKO contained 37.63% triglycerides, 48.37% phospholipids, 13.54% free fatty acids and 0.66% cholesterol, whereas the corresponding values for PKO were 0.59, 69.80, 28.53 and 1.09% respectively. Meanwhile, PKO contained much more polyunsaturated fatty acids (PUFA, 37.76%) than WKO (28.36%). After 4weeks of HCD consumption, plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and glucose increased significantly, but that of high-density lipoprotein cholesterol (HDL-C) decreased significantly. The intake of PKO and WKO for 4weeks caused a significant reduction in body weight gain and plasma levels of TC and LDL-C in HCD-fed rats. Compared with WKO, PKO was more effective in decreasing plasma TC and LDL-C levels. Conclusion: PKO showed better overall cholesterol-lowering effects than WKO, which may be due to its higher n-3 PUFA levels.

Original languageEnglish
Pages (from-to)2669-2675
Number of pages7
JournalJournal of the Science of Food and Agriculture
Volume93
Issue number11
DOIs
Publication statusPublished - Aug 30 2013

Fingerprint

Euphausiacea
krill
high fat diet
Oils
Cholesterol
cholesterol
Diet
Glucose
oils
glucose
rats
Phospholipids
phospholipids
low density lipoprotein cholesterol
LDL Cholesterol
cholesteremic effect
Omega-3 Fatty Acids
lipid composition
Unsaturated Fatty Acids
Nonesterified Fatty Acids

Keywords

  • Cholesterol-lowering effect
  • Glucose-lowering effect
  • High-cholesterol-fed rat
  • Krill oil
  • n-3 polyunsaturated fatty acids
  • Phospholipids

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Food Science
  • Nutrition and Dietetics
  • Biotechnology
  • Medicine(all)

Cite this

Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high-cholesterol diet. / Li, Dong Mei; Zhou, Da Yong; Zhu, Bei Wei; Chi, Ya Li; Sun, Li Ming; Dong, Xiu Ping; Qin, Lei; Qiao, Wei Zhou; Murata, Yoshiyuki.

In: Journal of the Science of Food and Agriculture, Vol. 93, No. 11, 30.08.2013, p. 2669-2675.

Research output: Contribution to journalArticle

Li, Dong Mei ; Zhou, Da Yong ; Zhu, Bei Wei ; Chi, Ya Li ; Sun, Li Ming ; Dong, Xiu Ping ; Qin, Lei ; Qiao, Wei Zhou ; Murata, Yoshiyuki. / Effects of krill oil intake on plasma cholesterol and glucose levels in rats fed a high-cholesterol diet. In: Journal of the Science of Food and Agriculture. 2013 ; Vol. 93, No. 11. pp. 2669-2675.
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AU - Sun, Li Ming

AU - Dong, Xiu Ping

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AU - Qiao, Wei Zhou

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