Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats

Kazuaki Shinomiya, Toshio Inoue, Yoshiaki Utsu, Shin Tokunaga, Takayoshi Masuoka, Asae Ohmori, Chiaki Kamei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Rationale: Kava-kava extract may be useful as an herbal medicine for treatment of insomnia and anxiety. Objectives: The present study was undertaken to investigate the effects of kava-kava extract on the sleep-wake cycle in comparison with that of flunitrazepam using sleep-disturbed rats. Methods: Electrodes for measurement of electroencephalogram (EEG) and electromyogram (EMG) were implanted into the frontal cortex and the dorsal neck muscle of rats. EEG and EMG were recorded with an electroencephalogram. SleepSign ver.2.0 was used for EEG and EMG analysis. Total times of wakefulness, non-rapid eye movement (non-REM) and REM sleep were measured from 09:00 to 15:00. Results: A significant shortening of the sleep latency in sleep-disturbed rats was observed following the administration of kava-kava extract at a dose of 300 mg/kg, while no effects were observed on the total waking and non-REM sleep time. On the other hand, flunitrazepam showed a significant shortening in sleep latency, decrease in total waking time and increase in total non-REM sleep time. Although the effects of flunitrazepam were antagonized by the benzodiazepine receptor antagonist flumazenil, the effect of kava-kava extract was not antagonized by flumazenil. Kava-kava extract showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with flunitrazepam. Flumazenil caused no significant effect on the changes in delta activity induced by both kava-kava extract and flunitrazepam. Conclusions: Kava-kava extract is an herbal medicine having not only hypnotic effects, but also sleep quality-enhancement effects.

Original languageEnglish
Pages (from-to)564-569
Number of pages6
JournalPsychopharmacology
Volume180
Issue number3
DOIs
Publication statusPublished - Jul 2005

Fingerprint

Kava
Sleep
Flunitrazepam
Eye Movements
Flumazenil
Electroencephalography
Electromyography
Herbal Medicine
Neck Muscles
Wakefulness
REM Sleep
Sleep Initiation and Maintenance Disorders
Frontal Lobe
GABA-A Receptors
Hypnotics and Sedatives

Keywords

  • Flunitrazepam
  • Hypnotics
  • Insomnia
  • Kava
  • Sleep-disturbed rats
  • Sleep-wake cycle

ASJC Scopus subject areas

  • Pharmacology

Cite this

Shinomiya, K., Inoue, T., Utsu, Y., Tokunaga, S., Masuoka, T., Ohmori, A., & Kamei, C. (2005). Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. Psychopharmacology, 180(3), 564-569. https://doi.org/10.1007/s00213-005-2196-4

Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. / Shinomiya, Kazuaki; Inoue, Toshio; Utsu, Yoshiaki; Tokunaga, Shin; Masuoka, Takayoshi; Ohmori, Asae; Kamei, Chiaki.

In: Psychopharmacology, Vol. 180, No. 3, 07.2005, p. 564-569.

Research output: Contribution to journalArticle

Shinomiya, K, Inoue, T, Utsu, Y, Tokunaga, S, Masuoka, T, Ohmori, A & Kamei, C 2005, 'Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats', Psychopharmacology, vol. 180, no. 3, pp. 564-569. https://doi.org/10.1007/s00213-005-2196-4
Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A et al. Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. Psychopharmacology. 2005 Jul;180(3):564-569. https://doi.org/10.1007/s00213-005-2196-4
Shinomiya, Kazuaki ; Inoue, Toshio ; Utsu, Yoshiaki ; Tokunaga, Shin ; Masuoka, Takayoshi ; Ohmori, Asae ; Kamei, Chiaki. / Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats. In: Psychopharmacology. 2005 ; Vol. 180, No. 3. pp. 564-569.
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