Effects of isoflurane-induced and prostaglandin E1-induced hypotension on cytokine responses to oral and maxillofacial surgery

Takuya Miyawaki, Atsushi Kohjitani, Shigeru Maeda, Hitoshi Higuchi, Masahiko Shimada

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Study objective To evaluate the effect of induced hypotension with isoflurane or prostaglandin E1 (PGE1) on cytokine responses to surgery. Design Prospective, randomized study. Setting University hospital. Patients 24 ASA physical status I and II patients undergoing elective oral and maxillofacial surgery. Interventions Patients were randomly allocated to three groups be anesthetized in the normotension (Control group), isoflurane-induced hypotension (Isoflurane-H group), and PGE1-induced hypotension (PGE1-H group). Mean arterial pressure during hypotension was maintained at approximately 80% of baseline values. Measurements and main results Blood samples were taken before induction of anesthesia and during and after hypotension. Plasma tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels were measured using enzyme-linked immunosorbent assay. There were no differences in TNF-α or IL-10 levels among the groups. However, the elevation of the plasma IL-6 level in the PGE1-H group was found during hypotension, compared with the control group (p < 0.05). Conclusions PGE 1-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalJournal of Clinical Anesthesia
Issue number3
Publication statusPublished - May 2004


  • Induced hypotension
  • cytokines, interleukin-6
  • isoflurane
  • oral and maxillofacial surgery
  • prostaglandin E

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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