TY - JOUR
T1 - Effects of isoflurane-induced and prostaglandin E1-induced hypotension on cytokine responses to oral and maxillofacial surgery
AU - Miyawaki, Takuya
AU - Kohjitani, Atsushi
AU - Maeda, Shigeru
AU - Higuchi, Hitoshi
AU - Shimada, Masahiko
N1 - Funding Information:
Supported by a Grant in Aid for Encouragement of Young Scientists 09771759 from the Ministry of Education, Science, Sports and Culture, Tokyo, Japan.
PY - 2004/5
Y1 - 2004/5
N2 - Study objective To evaluate the effect of induced hypotension with isoflurane or prostaglandin E1 (PGE1) on cytokine responses to surgery. Design Prospective, randomized study. Setting University hospital. Patients 24 ASA physical status I and II patients undergoing elective oral and maxillofacial surgery. Interventions Patients were randomly allocated to three groups be anesthetized in the normotension (Control group), isoflurane-induced hypotension (Isoflurane-H group), and PGE1-induced hypotension (PGE1-H group). Mean arterial pressure during hypotension was maintained at approximately 80% of baseline values. Measurements and main results Blood samples were taken before induction of anesthesia and during and after hypotension. Plasma tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels were measured using enzyme-linked immunosorbent assay. There were no differences in TNF-α or IL-10 levels among the groups. However, the elevation of the plasma IL-6 level in the PGE1-H group was found during hypotension, compared with the control group (p < 0.05). Conclusions PGE 1-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery.
AB - Study objective To evaluate the effect of induced hypotension with isoflurane or prostaglandin E1 (PGE1) on cytokine responses to surgery. Design Prospective, randomized study. Setting University hospital. Patients 24 ASA physical status I and II patients undergoing elective oral and maxillofacial surgery. Interventions Patients were randomly allocated to three groups be anesthetized in the normotension (Control group), isoflurane-induced hypotension (Isoflurane-H group), and PGE1-induced hypotension (PGE1-H group). Mean arterial pressure during hypotension was maintained at approximately 80% of baseline values. Measurements and main results Blood samples were taken before induction of anesthesia and during and after hypotension. Plasma tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels were measured using enzyme-linked immunosorbent assay. There were no differences in TNF-α or IL-10 levels among the groups. However, the elevation of the plasma IL-6 level in the PGE1-H group was found during hypotension, compared with the control group (p < 0.05). Conclusions PGE 1-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery.
KW - Induced hypotension
KW - cytokines, interleukin-6
KW - isoflurane
KW - oral and maxillofacial surgery
KW - prostaglandin E
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U2 - 10.1016/j.jclinane.2003.07.002
DO - 10.1016/j.jclinane.2003.07.002
M3 - Article
C2 - 15217654
AN - SCOPUS:3042558406
VL - 16
SP - 168
EP - 172
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
SN - 0952-8180
IS - 3
ER -