Abstract
Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature were studied in mice. Histamine (0.1-1.0 μg) and histidine (500-1,000 mg/kg) caused a dose-related hypothermia. H1 agonist, 2-methylhistamine and 2-thiazolylethylamine also displayed a dose-dependent hypothermia. In addition, H2 agonists, 4-methylhistamine and dimaprit elicited a decrease in body temperature. Preinjection of not only H1-antagonists (diphenhydramine and chlorpheniramine) but also H2 antagonists (cimetidine and ranitidine) abolished histamine-induced hypothermia. Either intracerebroventricular or intraperitoneal injection of thioperamide, a histamine H3 antagonist, showed hypothermia. The hypothermic effect produced by intracerebroventricular injection of thioperamide was significantly blocked by (R)-α-methylhistamine, a selective H3 agonist. In addition, the effect induced by thioperamide was inhibited by H1 and H2 antagonists, indicating that the H3 receptor also participates in histamine-induced hypothermia.
| Original language | English |
|---|---|
| Pages (from-to) | 669-675 |
| Number of pages | 7 |
| Journal | Methods and Findings in Experimental and Clinical Pharmacology |
| Volume | 17 |
| Issue number | 10 |
| Publication status | Published - 1995 |
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Keywords
- H receptor
- H receptor
- histamine
- hypothermia
- thioperamide
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature in mice. / Chen, Z.; Sugimoto, Yukio; Kamei, C.
In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 17, No. 10, 1995, p. 669-675.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature in mice
AU - Chen, Z.
AU - Sugimoto, Yukio
AU - Kamei, C.
PY - 1995
Y1 - 1995
N2 - Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature were studied in mice. Histamine (0.1-1.0 μg) and histidine (500-1,000 mg/kg) caused a dose-related hypothermia. H1 agonist, 2-methylhistamine and 2-thiazolylethylamine also displayed a dose-dependent hypothermia. In addition, H2 agonists, 4-methylhistamine and dimaprit elicited a decrease in body temperature. Preinjection of not only H1-antagonists (diphenhydramine and chlorpheniramine) but also H2 antagonists (cimetidine and ranitidine) abolished histamine-induced hypothermia. Either intracerebroventricular or intraperitoneal injection of thioperamide, a histamine H3 antagonist, showed hypothermia. The hypothermic effect produced by intracerebroventricular injection of thioperamide was significantly blocked by (R)-α-methylhistamine, a selective H3 agonist. In addition, the effect induced by thioperamide was inhibited by H1 and H2 antagonists, indicating that the H3 receptor also participates in histamine-induced hypothermia.
AB - Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature were studied in mice. Histamine (0.1-1.0 μg) and histidine (500-1,000 mg/kg) caused a dose-related hypothermia. H1 agonist, 2-methylhistamine and 2-thiazolylethylamine also displayed a dose-dependent hypothermia. In addition, H2 agonists, 4-methylhistamine and dimaprit elicited a decrease in body temperature. Preinjection of not only H1-antagonists (diphenhydramine and chlorpheniramine) but also H2 antagonists (cimetidine and ranitidine) abolished histamine-induced hypothermia. Either intracerebroventricular or intraperitoneal injection of thioperamide, a histamine H3 antagonist, showed hypothermia. The hypothermic effect produced by intracerebroventricular injection of thioperamide was significantly blocked by (R)-α-methylhistamine, a selective H3 agonist. In addition, the effect induced by thioperamide was inhibited by H1 and H2 antagonists, indicating that the H3 receptor also participates in histamine-induced hypothermia.
KW - H receptor
KW - H receptor
KW - histamine
KW - hypothermia
KW - thioperamide
UR - http://www.scopus.com/inward/record.url?scp=0029609889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029609889&partnerID=8YFLogxK
M3 - Article
C2 - 9053587
AN - SCOPUS:0029609889
VL - 17
SP - 669
EP - 675
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
SN - 0379-0355
IS - 10
ER -