Abstract
Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature were studied in mice. Histamine (0.1-1.0 μg) and histidine (500-1,000 mg/kg) caused a dose-related hypothermia. H1 agonist, 2-methylhistamine and 2-thiazolylethylamine also displayed a dose-dependent hypothermia. In addition, H2 agonists, 4-methylhistamine and dimaprit elicited a decrease in body temperature. Preinjection of not only H1-antagonists (diphenhydramine and chlorpheniramine) but also H2 antagonists (cimetidine and ranitidine) abolished histamine-induced hypothermia. Either intracerebroventricular or intraperitoneal injection of thioperamide, a histamine H3 antagonist, showed hypothermia. The hypothermic effect produced by intracerebroventricular injection of thioperamide was significantly blocked by (R)-α-methylhistamine, a selective H3 agonist. In addition, the effect induced by thioperamide was inhibited by H1 and H2 antagonists, indicating that the H3 receptor also participates in histamine-induced hypothermia.
| Original language | English |
|---|---|
| Pages (from-to) | 669-675 |
| Number of pages | 7 |
| Journal | Methods and Findings in Experimental and Clinical Pharmacology |
| Volume | 17 |
| Issue number | 10 |
| Publication status | Published - Dec 1 1995 |
Keywords
- H receptor
- H receptor
- histamine
- hypothermia
- thioperamide
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)