Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis

Haruka Fujimoto, Tomomi Noguchi, Hisayoshi Kobayashi, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3, 5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on HL-60 cells and anti-angiogenic activity on human umbilical vein endothelial cells (HUVEC). AIDO-00 (7) also showed anti-angiogenic activity. NIDO-11 (8) showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation, and AIDO-30 (13) exhibited cyclooxygenase (COX)-inhibitory activity.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 1 2006

Keywords

  • Angiogenesis
  • Cyclooxygenase
  • Differentiation
  • Immunomodulatory derivative of thalidomide (IMiD)
  • Thalidomide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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