Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis

Haruka Fujimoto, Tomomi Noguchi, Hisayoshi Kobayashi, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Various analogs of known immunomodulatory derivatives of thalidomide (1) (IMiDs: 3, 5) were synthesized, focusing on cell-differentiation-inducing, cyclooxygenase-inhibitory and anti-angiogenesis activities. Among the prepared compounds, NIDO-33 (14) showed cell differentiation-inducing activity on HL-60 cells and anti-angiogenic activity on human umbilical vein endothelial cells (HUVEC). AIDO-00 (7) also showed anti-angiogenic activity. NIDO-11 (8) showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation, and AIDO-30 (13) exhibited cyclooxygenase (COX)-inhibitory activity.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

Fingerprint

Thalidomide
Prostaglandin-Endoperoxide Synthases
Cell Differentiation
HL-60 Cells
Derivatives
Endothelial cells
Tretinoin
Human Umbilical Vein Endothelial Cells

Keywords

  • Angiogenesis
  • Cyclooxygenase
  • Differentiation
  • Immunomodulatory derivative of thalidomide (IMiD)
  • Thalidomide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis. / Fujimoto, Haruka; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 54, No. 6, 06.2006, p. 855-860.

Research output: Contribution to journalArticle

Fujimoto, Haruka ; Noguchi, Tomomi ; Kobayashi, Hisayoshi ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis. In: Chemical and Pharmaceutical Bulletin. 2006 ; Vol. 54, No. 6. pp. 855-860.
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