Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats

Yoshihisa Kitamura, Kozue Akiyama, Shinji Hashimoto, Kouhei Kitagawa, Hiromu Kawasaki, Kazuhiko Shibata, Kazuaki Shinomiya, Katsuya Suemaru, Hiroaki Araki, Toshiaki Sendo, Yutaka Gomita

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Abstract

We investigated the effect of imipramine on extracellular serotonin (5-HT) and noradrenaline concentrations in the medial prefrontal cortex of rats treated with adrenocorticotropic hormone (ACTH) for 14 days using in vivo microdialysis. Chronic ACTH treatment did not affect basal extracellular 5-HT and noradrenaline concentrations compared with chronic saline treatment. Acute imipramine treatment plus chronic ACTH treatment significantly increased extracellular 5-HT concentrations, compared with imipramine treatment alone. 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a 5-HT1A receptors full agonist, caused a significant decrease in extracellular 5-HT concentrations. However, its inhibitory effect was attenuated by the treatment with ACTH for 14 days. These findings suggest that chronic treatment with ACTH enhances the increasing effect release of 5-HT by imipramine through the desensitization of somatodendritic 5-HT1A autoreceptors.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalEuropean Journal of Pharmacology
Volume566
Issue number1-3
DOIs
Publication statusPublished - Jul 2 2007

Keywords

  • 5-HT receptor
  • 8-hydroxy-2-di-n-propylamino tetralin
  • Adrenocorticotropic hormone
  • Imipramine
  • Microdialysis

ASJC Scopus subject areas

  • Pharmacology

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    Kitamura, Y., Akiyama, K., Hashimoto, S., Kitagawa, K., Kawasaki, H., Shibata, K., Shinomiya, K., Suemaru, K., Araki, H., Sendo, T., & Gomita, Y. (2007). Effects of imipramine on extracellular serotonin and noradrenaline concentrations in ACTH-treated rats. European Journal of Pharmacology, 566(1-3), 113-116. https://doi.org/10.1016/j.ejphar.2007.03.012