Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats

Yoshihisa Kitamura, Hiroaki Araki, Katsuya Suemaru, Yutaka Gomita

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume72
Issue number1-2
DOIs
Publication statusPublished - 2002

Fingerprint

Receptor, Serotonin, 5-HT2A
Imipramine
Lithium
Adrenocorticotropic Hormone
Rats
Dogs
Serotonin 5-HT2 Receptor Agonists

Keywords

  • 5-HT receptor
  • ACTH
  • Imipramine
  • Lithium
  • Wet-dog shake

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats. / Kitamura, Yoshihisa; Araki, Hiroaki; Suemaru, Katsuya; Gomita, Yutaka.

In: Pharmacology Biochemistry and Behavior, Vol. 72, No. 1-2, 2002, p. 397-402.

Research output: Contribution to journalArticle

@article{b3e0a1a7688344b39af523c647641f03,
title = "Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats",
abstract = "We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.",
keywords = "5-HT receptor, ACTH, Imipramine, Lithium, Wet-dog shake",
author = "Yoshihisa Kitamura and Hiroaki Araki and Katsuya Suemaru and Yutaka Gomita",
year = "2002",
doi = "10.1016/S0091-3057(01)00769-9",
language = "English",
volume = "72",
pages = "397--402",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "1-2",

}

TY - JOUR

T1 - Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats

AU - Kitamura, Yoshihisa

AU - Araki, Hiroaki

AU - Suemaru, Katsuya

AU - Gomita, Yutaka

PY - 2002

Y1 - 2002

N2 - We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.

AB - We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.

KW - 5-HT receptor

KW - ACTH

KW - Imipramine

KW - Lithium

KW - Wet-dog shake

UR - http://www.scopus.com/inward/record.url?scp=0036207686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036207686&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(01)00769-9

DO - 10.1016/S0091-3057(01)00769-9

M3 - Article

VL - 72

SP - 397

EP - 402

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 1-2

ER -