Abstract
We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
| Original language | English |
|---|---|
| Pages (from-to) | 397-402 |
| Number of pages | 6 |
| Journal | Pharmacology Biochemistry and Behavior |
| Volume | 72 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- 5-HT receptor
- ACTH
- Imipramine
- Lithium
- Wet-dog shake
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats. / Kitamura, Yoshihisa; Araki, Hiroaki; Suemaru, Katsuya; Gomita, Yutaka.
In: Pharmacology Biochemistry and Behavior, Vol. 72, No. 1-2, 2002, p. 397-402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of imipramine and lithium on wet-dog shakes mediated by the 5-HT2A receptor in ACTH-treated rats
AU - Kitamura, Yoshihisa
AU - Araki, Hiroaki
AU - Suemaru, Katsuya
AU - Gomita, Yutaka
PY - 2002
Y1 - 2002
N2 - We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
AB - We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
KW - 5-HT receptor
KW - ACTH
KW - Imipramine
KW - Lithium
KW - Wet-dog shake
UR - http://www.scopus.com/inward/record.url?scp=0036207686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036207686&partnerID=8YFLogxK
U2 - 10.1016/S0091-3057(01)00769-9
DO - 10.1016/S0091-3057(01)00769-9
M3 - Article
VL - 72
SP - 397
EP - 402
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
SN - 0091-3057
IS - 1-2
ER -