Abstract
We examined the influence of imipramine and lithium on wet-dog shakes induced by the (±)-DOI, 5-HT2A receptor agonist in adrenocorticotropic hormone (ACTH)-treated rats. The administration of imipramine for 14 days decreased the (±)-DOI-induced wet-dog shakes response; chronic administration of lithium for 14 days, however, had no effect. Chronic ACTH (100 μg/rat sc) treatment increased the wet-dog shake response induced by (±)-DOI. This effect of ACTH for 14 days, increasing the (±)-DOI-induced wet-dog shakes, was not inhibited by a 14-day administration of imipramine. Chronic coadministration of imipramine and lithium, lasting 14 days, decreased the wet-dog shakes response induced by (±)-DOI in rats treated with ACTH for 14 days. These findings indicate that lithium inhibits the hyperfunction of the 5-HT2A receptor in rats treated with ACTH when coadministered with imipramine.
Original language | English |
---|---|
Pages (from-to) | 397-402 |
Number of pages | 6 |
Journal | Pharmacology Biochemistry and Behavior |
Volume | 72 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Apr 6 2002 |
Keywords
- 5-HT receptor
- ACTH
- Imipramine
- Lithium
- Wet-dog shake
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience