Effects of hydrogen-rich water on aging periodontal tissues in rats

Takaaki Tomofuji, Yuya Kawabata, Kenta Kasuyama, Yasumasa Endo, Toshiki Yoneda, Mayu Yamane, Tetsuji Azuma, Daisuke Ekuni, Manabu Morita

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β 2 did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.

Original languageEnglish
Article number5534
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - Jul 2 2014

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Hydrogen
Water
Water Purification
Control Groups
Drinking
Inflammasomes
Inbred F344 Rats
Interleukin-1
Interleukin-2
Proteins
Age Groups
Gene Expression

ASJC Scopus subject areas

  • General
  • Medicine(all)

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Effects of hydrogen-rich water on aging periodontal tissues in rats. / Tomofuji, Takaaki; Kawabata, Yuya; Kasuyama, Kenta; Endo, Yasumasa; Yoneda, Toshiki; Yamane, Mayu; Azuma, Tetsuji; Ekuni, Daisuke; Morita, Manabu.

In: Scientific Reports, Vol. 4, 5534, 02.07.2014.

Research output: Contribution to journalArticle

Tomofuji, Takaaki ; Kawabata, Yuya ; Kasuyama, Kenta ; Endo, Yasumasa ; Yoneda, Toshiki ; Yamane, Mayu ; Azuma, Tetsuji ; Ekuni, Daisuke ; Morita, Manabu. / Effects of hydrogen-rich water on aging periodontal tissues in rats. In: Scientific Reports. 2014 ; Vol. 4.
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