Effects of HMGB1 on ischemia-reperfusion injury in the rat heart

Susumu Oozawa, Shuji Mori, Tom Kanke, Hideo Takahashi, Keyue Liu, Yasuko Tomono, Masato Asanuma, Ikuko Miyazaki, Masahiro Nishibori, Shunji Sano

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background Coronary ischemia-reperfusion (I/R) injury causes cardiomyocyte necrosis in a multi-step process that includes an inflammatory reaction. A recent study has suggested that high-mobility group box 1 (HMGB1) is a late mediator of lethal sepsis and an early mediator of inflammation and necrosis following I/R injury. In the present study a neutralizing monoclonal antibody (mAb) for HMGB1 was used to clarify the role of HMGB1 in cardiac I/R injury. Methods and Results Rats underwent 30min of left coronary artery occlusion followed by 60min reperfusion. An intravenous injection of anti-HMGB1 mAb or control IgG was administered just before reperfusion. The infarct size was enlarged in the anti-HMGB1 mAb group in comparison with the control group (p

Original languageEnglish
Pages (from-to)1178-1184
Number of pages7
JournalCirculation Journal
Volume72
Issue number7
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Reperfusion Injury
Monoclonal Antibodies
Reperfusion
Necrosis
Inflammation Mediators
Myocardial Reperfusion
Coronary Occlusion
Neutralizing Antibodies
Cardiac Myocytes
Intravenous Injections
Sepsis
Coronary Vessels
Immunoglobulin G
Control Groups

Keywords

  • Coronary ischemia-reperfusion injury
  • HMGB1
  • Norepinephrine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Oozawa, S., Mori, S., Kanke, T., Takahashi, H., Liu, K., Tomono, Y., ... Sano, S. (2008). Effects of HMGB1 on ischemia-reperfusion injury in the rat heart. Circulation Journal, 72(7), 1178-1184. https://doi.org/10.1253/circj.72.1178

Effects of HMGB1 on ischemia-reperfusion injury in the rat heart. / Oozawa, Susumu; Mori, Shuji; Kanke, Tom; Takahashi, Hideo; Liu, Keyue; Tomono, Yasuko; Asanuma, Masato; Miyazaki, Ikuko; Nishibori, Masahiro; Sano, Shunji.

In: Circulation Journal, Vol. 72, No. 7, 2008, p. 1178-1184.

Research output: Contribution to journalArticle

Oozawa, Susumu ; Mori, Shuji ; Kanke, Tom ; Takahashi, Hideo ; Liu, Keyue ; Tomono, Yasuko ; Asanuma, Masato ; Miyazaki, Ikuko ; Nishibori, Masahiro ; Sano, Shunji. / Effects of HMGB1 on ischemia-reperfusion injury in the rat heart. In: Circulation Journal. 2008 ; Vol. 72, No. 7. pp. 1178-1184.
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