Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT

S. Isayama, Yukio Sugimoto, M. Nishiga, C. Kamei

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We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

Original languageEnglish
Pages (from-to)451-453
Number of pages3
JournalJapanese Journal of Pharmacology
Issue number4
Publication statusPublished - 2001



  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Histidine
  • Radial maze performance

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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