Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT

S. Isayama, Yukio Sugimoto, M. Nishiga, C. Kamei

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

Original languageEnglish
Pages (from-to)451-453
Number of pages3
JournalJapanese Journal of Pharmacology
Volume86
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Serotonin 5-HT1 Receptor Agonists
8-Hydroxy-2-(di-n-propylamino)tetralin
Receptor, Serotonin, 5-HT1A
Memory Disorders
Short-Term Memory
Histidine
Histamine
hydroxide ion
Brain

Keywords

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Histidine
  • Radial maze performance

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT. / Isayama, S.; Sugimoto, Yukio; Nishiga, M.; Kamei, C.

In: Japanese Journal of Pharmacology, Vol. 86, No. 4, 2001, p. 451-453.

Research output: Contribution to journalArticle

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