Abstract
The effects of histamine on the spatial memory deficits induced by MK- 801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2- thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H1-receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 186-189 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 839 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Aug 21 1999 |
Keywords
- H-receptor
- H-receptor
- Histamine
- MK-801
- Radial maze performance
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Fingerprint Dive into the research topics of 'Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats'. Together they form a unique fingerprint.
Cite this
Chen, Z., Zhao, Q., Sugimoto, Y., Fujii, Y., & Kamei, C. (1999). Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats. Brain Research, 839(1), 186-189. https://doi.org/10.1016/S0006-8993(99)01739-4