Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

Zhong Chen, Quie Zhao, Yukio Sugimoto, Yoko Fujii, Chiaki Kamei

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The effects of histamine on the spatial memory deficits induced by MK- 801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2- thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H1-receptors.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalBrain Research
Volume839
Issue number1
DOIs
Publication statusPublished - Aug 21 1999

Keywords

  • H-receptor
  • H-receptor
  • Histamine
  • MK-801
  • Radial maze performance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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