Abstract
The effects of histamine on the spatial memory deficits induced by MK- 801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2- thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H1-receptors.
Original language | English |
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Pages (from-to) | 186-189 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 839 |
Issue number | 1 |
DOIs | |
Publication status | Published - Aug 21 1999 |
Keywords
- H-receptor
- H-receptor
- Histamine
- MK-801
- Radial maze performance
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology