Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

Zhong Chen; Quie Zhao; Yukio Sugimoto; Yoko Fujii; Chiaki Kamei

doi:10.1016/S0006-8993(99)01739-4

Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

Zhong Chen, Quie Zhao, Yukio Sugimoto, Yoko Fujii, Chiaki Kamei

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

The effects of histamine on the spatial memory deficits induced by MK- 801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2- thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H₁-receptors.

Original language	English
Pages (from-to)	186-189
Number of pages	4
Journal	Brain Research
Volume	839
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(99)01739-4
Publication status	Published - Aug 21 1999

Keywords

H-receptor
H-receptor
Histamine
MK-801
Radial maze performance

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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AU - Sugimoto, Yukio

AU - Fujii, Yoko

AU - Kamei, Chiaki

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AB - The effects of histamine on the spatial memory deficits induced by MK- 801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2- thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H1-receptors.

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KW - MK-801

KW - Radial maze performance

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Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

Abstract

Keywords

ASJC Scopus subject areas

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