Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice

Yukio Sugimoto, Keiko Umakoshi, Nao Nojiri, Chiaki Kamei

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

The effects of histamine H1 receptor antagonists on compound 48/80- induced scratching behavior were studied in mice. Classical histamine H1 receptor antagonists such as diphenhydramine and chlorpheniramine caused a potent depressant effect on compound 48/80-induced scratching behavior. Histamine H1 receptor antagonists having antiallergic activity (an inhibition of mast cell degranulation), such as azelastine and oxatomide and nonsedative histamine H1 receptor antagonists such as terfenadine, epinastine and astemizole, also showed a relatively potent effect. On the other hand, the effects of tranilast and cromolyn sodium-antiallergic drugs without histamine H1 receptor antagonistic activity-were extremely weak. Diazepam had weak or no depressant effects on compound 48/80-induced scratching behavior. These results suggest that inhibition of compound 48/80- induced scratching behavior is mainly due to histamine H1 receptor antagonistic activity and not to the sedative action of the drugs.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEuropean Journal of Pharmacology
Volume351
Issue number1
DOIs
Publication statusPublished - Jun 12 1998

Keywords

  • Antiallergic drug
  • Compound 48/80
  • Histamine H receptor antagonist
  • Scratching behavior

ASJC Scopus subject areas

  • Pharmacology

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