Effects of histamine and related compounds on regional cerebral blood flow in rats

G. Suzuki, Z. Chen, Y. Sugimoto, Y. Fujii, C. Kamei

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The effects of histamine and related compounds on regional cerebral blood flow (rCBF) in the hippocampus of conscious rats were studied. Intracerebroventricular injection of histamine caused a dose-dependent increase in rCBF in the hippocampus, and similar findings were observed with not only the H1 agonist, 2-thiazolylethylamine, but also the H2 agonist, dimaprit. Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of histamine content in the brain. The increase in rCBF in the hippocampus induced by L- histidine was antagonized by both H1 and H2 antagonists (diphenhydramine, pyrilamine and zolantidine). In addition, when both antagonists were injected simultaneously, an additive effect was observed in antagonism of the L- histidine-induced increase in rCBF. L-Histidine caused no marked changes in blood pressure even at a dose of 1,500 mg/kg, which showed an increase in rCBF in the hippocampus. These results indicate that histamine elicited an increase in rCBF via both H1 and H2 receptors.

Original languageEnglish
Pages (from-to)613-617
Number of pages5
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume21
Issue number9
Publication statusPublished - Dec 1 1999

Keywords

  • H Agonist
  • H Agonist
  • Histamine
  • L-Histidine
  • Regional cerebral blood flow

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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