Effects of histamine and related compounds on regional cerebral blood flow in rats

G. Suzuki, Z. Chen, Y. Sugimoto, Y. Fujii, C. Kamei

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of histamine and related compounds on regional cerebral blood flow (rCBF) in the hippocampus of conscious rats were studied. Intracerebroventricular injection of histamine caused a dose-dependent increase in rCBF in the hippocampus, and similar findings were observed with not only the H1 agonist, 2-thiazolylethylamine, but also the H2 agonist, dimaprit. Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of histamine content in the brain. The increase in rCBF in the hippocampus induced by L- histidine was antagonized by both H1 and H2 antagonists (diphenhydramine, pyrilamine and zolantidine). In addition, when both antagonists were injected simultaneously, an additive effect was observed in antagonism of the L- histidine-induced increase in rCBF. L-Histidine caused no marked changes in blood pressure even at a dose of 1,500 mg/kg, which showed an increase in rCBF in the hippocampus. These results indicate that histamine elicited an increase in rCBF via both H1 and H2 receptors.

Original languageEnglish
Pages (from-to)613-617
Number of pages5
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume21
Issue number9
Publication statusPublished - Dec 1 1999

Keywords

  • H Agonist
  • H Agonist
  • Histamine
  • L-Histidine
  • Regional cerebral blood flow

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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