Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice

Miwa Baba, Masahiro Nishibori, Ryozo Oishi, Kiyomi Saeki, Futami Kosaka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of halothane, enflurane, ketamine and pentobarbital on brain histamine dynamics were examined in mice. Brain histamine and tele-methylhistamine, a predominant metabolite of brain histamine, were simultaneously measured by high-performance liquid chromatography with fluorescence detection. Anaesthesia with the four agents had no effect on brain histamine content. The tele-methylhistamine content significantly increased during 1 h and 2 h anaesthesia with halothane (0.051 mmol/l or 0.076 mol/1) and 2 h anaesthesia with enflurane (0.11 mol/l or 0.16 mol/1). Enflurane and pentobarbital significantly inhibited the histamine depletion induced by α-fluoromethylhistidine (50 mg/kg, intraperitoneally), a specific inhibitor of histidine decarboxylase, suggesting that these agents decrease the histamine turnover. However, halothane and ketamine were ineffective in this respect. These results emphasize that various anaesthetics have different influences on brain histamine dynamics. Since there have been findings suggesting that brain histaminergic systems are involved in physiological functions such as regulation of blood pressure, body temperature and hormone secretion, changes in the brain histamine turnover should be given due attention with regard to physiological changes during anaesthesia.

Original languageEnglish
Pages (from-to)686-691
Number of pages6
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume335
Issue number6
DOIs
Publication statusPublished - 1987

Fingerprint

Enflurane
Halothane
Pentobarbital
Histamine
Brain
Anesthesia
Ketamine
Histamine Agents
Histidine Decarboxylase
Body Temperature
Anesthetics
Fluorescence
High Pressure Liquid Chromatography
Hormones
Blood Pressure

Keywords

  • Enflurane
  • Halothane
  • Histamine turnover
  • Ketamine
  • Pentobarbital

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice. / Baba, Miwa; Nishibori, Masahiro; Oishi, Ryozo; Saeki, Kiyomi; Kosaka, Futami.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 335, No. 6, 1987, p. 686-691.

Research output: Contribution to journalArticle

Baba, Miwa ; Nishibori, Masahiro ; Oishi, Ryozo ; Saeki, Kiyomi ; Kosaka, Futami. / Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice. In: Naunyn-Schmiedeberg's Archives of Pharmacology. 1987 ; Vol. 335, No. 6. pp. 686-691.
@article{228bb07f9a6d43c99e63ac07b8b7c3d5,
title = "Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice",
abstract = "The effects of halothane, enflurane, ketamine and pentobarbital on brain histamine dynamics were examined in mice. Brain histamine and tele-methylhistamine, a predominant metabolite of brain histamine, were simultaneously measured by high-performance liquid chromatography with fluorescence detection. Anaesthesia with the four agents had no effect on brain histamine content. The tele-methylhistamine content significantly increased during 1 h and 2 h anaesthesia with halothane (0.051 mmol/l or 0.076 mol/1) and 2 h anaesthesia with enflurane (0.11 mol/l or 0.16 mol/1). Enflurane and pentobarbital significantly inhibited the histamine depletion induced by α-fluoromethylhistidine (50 mg/kg, intraperitoneally), a specific inhibitor of histidine decarboxylase, suggesting that these agents decrease the histamine turnover. However, halothane and ketamine were ineffective in this respect. These results emphasize that various anaesthetics have different influences on brain histamine dynamics. Since there have been findings suggesting that brain histaminergic systems are involved in physiological functions such as regulation of blood pressure, body temperature and hormone secretion, changes in the brain histamine turnover should be given due attention with regard to physiological changes during anaesthesia.",
keywords = "Enflurane, Halothane, Histamine turnover, Ketamine, Pentobarbital",
author = "Miwa Baba and Masahiro Nishibori and Ryozo Oishi and Kiyomi Saeki and Futami Kosaka",
year = "1987",
doi = "10.1007/BF00166987",
language = "English",
volume = "335",
pages = "686--691",
journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",
issn = "0028-1298",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Effects of halothane, enflurane and pentobarbital on brain histamine dynamics in mice

AU - Baba, Miwa

AU - Nishibori, Masahiro

AU - Oishi, Ryozo

AU - Saeki, Kiyomi

AU - Kosaka, Futami

PY - 1987

Y1 - 1987

N2 - The effects of halothane, enflurane, ketamine and pentobarbital on brain histamine dynamics were examined in mice. Brain histamine and tele-methylhistamine, a predominant metabolite of brain histamine, were simultaneously measured by high-performance liquid chromatography with fluorescence detection. Anaesthesia with the four agents had no effect on brain histamine content. The tele-methylhistamine content significantly increased during 1 h and 2 h anaesthesia with halothane (0.051 mmol/l or 0.076 mol/1) and 2 h anaesthesia with enflurane (0.11 mol/l or 0.16 mol/1). Enflurane and pentobarbital significantly inhibited the histamine depletion induced by α-fluoromethylhistidine (50 mg/kg, intraperitoneally), a specific inhibitor of histidine decarboxylase, suggesting that these agents decrease the histamine turnover. However, halothane and ketamine were ineffective in this respect. These results emphasize that various anaesthetics have different influences on brain histamine dynamics. Since there have been findings suggesting that brain histaminergic systems are involved in physiological functions such as regulation of blood pressure, body temperature and hormone secretion, changes in the brain histamine turnover should be given due attention with regard to physiological changes during anaesthesia.

AB - The effects of halothane, enflurane, ketamine and pentobarbital on brain histamine dynamics were examined in mice. Brain histamine and tele-methylhistamine, a predominant metabolite of brain histamine, were simultaneously measured by high-performance liquid chromatography with fluorescence detection. Anaesthesia with the four agents had no effect on brain histamine content. The tele-methylhistamine content significantly increased during 1 h and 2 h anaesthesia with halothane (0.051 mmol/l or 0.076 mol/1) and 2 h anaesthesia with enflurane (0.11 mol/l or 0.16 mol/1). Enflurane and pentobarbital significantly inhibited the histamine depletion induced by α-fluoromethylhistidine (50 mg/kg, intraperitoneally), a specific inhibitor of histidine decarboxylase, suggesting that these agents decrease the histamine turnover. However, halothane and ketamine were ineffective in this respect. These results emphasize that various anaesthetics have different influences on brain histamine dynamics. Since there have been findings suggesting that brain histaminergic systems are involved in physiological functions such as regulation of blood pressure, body temperature and hormone secretion, changes in the brain histamine turnover should be given due attention with regard to physiological changes during anaesthesia.

KW - Enflurane

KW - Halothane

KW - Histamine turnover

KW - Ketamine

KW - Pentobarbital

UR - http://www.scopus.com/inward/record.url?scp=0023221044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023221044&partnerID=8YFLogxK

U2 - 10.1007/BF00166987

DO - 10.1007/BF00166987

M3 - Article

C2 - 3627285

AN - SCOPUS:0023221044

VL - 335

SP - 686

EP - 691

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

SN - 0028-1298

IS - 6

ER -