Effects of Growth Hormone Treatment on Lipid Profiles

Toshihide Kubo, Mahoko Furujo, Kyohei Takahashi, Yuki Hyodo, Hiroki Tsuchiya, Mariko Hattori, Shoko Fujinaga, Kenji Urayama

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objectives: To assess the effects of growth hormone (GH) on lipid profiles in children and whether the effect is pharmacological. Methods: The authors determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and low-density lipoprotein cholesterol (LDL-C) every year during 3-y GH treatment in 48 GH deficient (GHD) short children and 22 children with short stature born small for gestational age (SGA). Results: The abnormally high levels of TC, non-HDL-C, and LDL-C showed a high frequency in GHD short children compared with epidemiological studies in Japan. The high prevalence of high level of TC was also shown in SGA short children. Three-year GH treatment decreased serum TC, non-HDL-C, and LDL-C levels in both patient groups. Conclusions: GH treatment is clearly a pharmacological therapy in SGA short children and so may also be in GHD short children at the Japanese standard therapeutic dose. Taken together, GH improves lipid profiles, and its effect has the possibility of medical properties.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalIndian Journal of Pediatrics
Volume85
Issue number4
DOIs
Publication statusPublished - Apr 1 2018
Externally publishedYes

Keywords

  • Cholesterol
  • Growth hormone
  • Growth hormone deficiency
  • Lipid
  • Small for gestational age

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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