Effects of growth hormone reduction in a patient with polycystic ovary syndrome complicated with acromegaly

Junko Goto, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto, Jiro Suzuki, Tomoko Miyoshi, Toshio Ogura, Yasuhiko Kamada, Hirofumi Makino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a rare case of polycystic ovary syndrome (PCOS) complicated with acromegaly due to a growth hormone (GH)-producing pituitary adenoma. Complete removal of the pituitary adenoma successfully reduced circulating levels of GH and insulin-like growth factor (IGF)-l, which, in turn, resulted in the amelioration of gonadal dysfunction, hyperandrogenism, lutenizing hormone hypersecretion, and severe insulin resistance. This clinical complication suggests that activation of systemic GH-IGF-1 axis is potentially involved in the development of PCOS.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalEndocrine journal
Volume56
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Acromegaly
  • Growth hormone
  • Hyperglycemia
  • Insulin-like growth factor-1
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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