To investigate the possible role of lipid peroxidation which causes by ischemia-reperfusion of middle cerebral artery, brain edema, cerebral and serum lipid peroxides and SOD activity were examined. The effects of glycyrrhizin administration on these parameters were also studied. When blood reperfusion was allowed 24 hours after 20 min ischemia, the level of lipid peroxides both in cerebral and serum increased significantly, while content of SOD both in cerebral and serum showed a decreasing tendency. However, brain edema was not observed. Subcutaneous injection of glycyrrhizin (100 mg/kg) for 3 days prior to following transient middle cerebral artery occlusion significantly suppressed the rise in lipid peroxides both in cerebral and serum and improved the decline to content of SOD. These results indicate that glycyrrhizin plays a role in protecting ischemic cellular damages by scavenging free radicals and lipid peroxides.
|Number of pages||9|
|Journal||Japanese Pharmacology and Therapeutics|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Pharmacology (medical)