TY - JOUR
T1 - Effects of gastric distension and electrical stimulation of dorsomedial medulla on neurons in parabrachial nucleus of rats
AU - Suemori, Kazuhiko
AU - Kobashi, Motoi
AU - Adachi, Akira
N1 - Funding Information:
This work was supported by Grant-in-Aid for Encouragement of Young Scientists 05771515 from the Ministry of Education, Science and Culture of Japan, and Grant-in-Aid for General Scientific Research 05454502 from the Ministry of Education, Science and Culture of Japan.
PY - 1994/8
Y1 - 1994/8
N2 - The effects of gastric distension and electrical stimulation of the dorsomedial medulla on neurons within the parabrachial nucleus (PB) were investigated electrophysiologically in urethane-chlorarose anesthetized rats. Among 74 neurons tested, electrical stimulation of the nucleus of the solitary tract (NTS) excited 30 neurons (excitatory neurons) and inhibited 14 neurons (inhibitory neurons). Fourteen neurons increased and 12 neurons decreased their discharge rates in response to gastric distension. Twenty-two neurons responded to both electrical stimulation of the NTS and gastric distension. Both excitatory and inhibitory neurons showed either an increase or a decrease in discharge rate responding to gastric distension. Furthermore, three neurons that decreased their discharge rates and two neurons that increased their discharge rates during gastric distension also responded to intravenous administration of metaraminol indicating some effect of baroreceptor activation on the neural activity. The responses of another 49 neurons in the PB to electrical stimulation of area postrema and gastric distension were analyzed. Electrical stimulation of the AP excited 14 neurons and inhibited only one neuron. Five neurons increased and seven neurons decreased their discharge rates in response to gastric distension. Only one inhibitory neuron responded to gastric distension. These observations suggested that the PB neurons received gastric mechanoreceptive inputs from the NTS.
AB - The effects of gastric distension and electrical stimulation of the dorsomedial medulla on neurons within the parabrachial nucleus (PB) were investigated electrophysiologically in urethane-chlorarose anesthetized rats. Among 74 neurons tested, electrical stimulation of the nucleus of the solitary tract (NTS) excited 30 neurons (excitatory neurons) and inhibited 14 neurons (inhibitory neurons). Fourteen neurons increased and 12 neurons decreased their discharge rates in response to gastric distension. Twenty-two neurons responded to both electrical stimulation of the NTS and gastric distension. Both excitatory and inhibitory neurons showed either an increase or a decrease in discharge rate responding to gastric distension. Furthermore, three neurons that decreased their discharge rates and two neurons that increased their discharge rates during gastric distension also responded to intravenous administration of metaraminol indicating some effect of baroreceptor activation on the neural activity. The responses of another 49 neurons in the PB to electrical stimulation of area postrema and gastric distension were analyzed. Electrical stimulation of the AP excited 14 neurons and inhibited only one neuron. Five neurons increased and seven neurons decreased their discharge rates in response to gastric distension. Only one inhibitory neuron responded to gastric distension. These observations suggested that the PB neurons received gastric mechanoreceptive inputs from the NTS.
KW - Area postrema
KW - Gastric distension
KW - Mechanoreceptor
KW - Nucleus of the solitary tract
KW - Parabrachial nucleus
KW - Stomach
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U2 - 10.1016/0165-1838(94)90051-5
DO - 10.1016/0165-1838(94)90051-5
M3 - Article
C2 - 7963257
AN - SCOPUS:0028237893
VL - 48
SP - 221
EP - 229
JO - Journal of the Autonomic Nervous System
JF - Journal of the Autonomic Nervous System
SN - 1566-0702
IS - 3
ER -