Effects of galantamine on l-NAME-induced behavioral impairment in Y-maze task in mice

Ken ichi Tanaka, Takao Yagi, Ryosuke Shimakoshi, Koji Azuma, Takeshi Nanba, Hiroya Ogo, Akiko Tamura, Masato Asanuma

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20 Citations (Scopus)

Abstract

Nitric oxide (NO) may play a role in the established processes of learning and memory. We examined the effects of Nω-nitro-l-arginine methylester (l-NAME), a nonselective inhibitor of NO synthase (NOS), on the performance of mice in a Y-maze task. l-NAME (100 mg/kg) markedly impaired spontaneous alternation behavior. However, galantamine (0.5 mg/kg) significantly attenuated this l-NAME-induced impairment. To clarify the molecular basis underlying galantamine's protective effects against l-NAME-induced impairment of spontaneous alternation behavior, we tested the ability of mecamylamine, an antagonist of nicotinic ACh receptor (nAChR), and scopolamine, an antagonist of muscarinic ACh receptor, to reduce galantamine's protective effects, and found that only the former had such an ability. Galantamine significantly also reduced l-NAME-induced decreases in NOx levels. However, mecamylamine cancelled galantamine's efficacy in countering the l-NAME-induced decrease in NOx levels. In the present study, we have determined that galantamine's protection against l-NAME-induced impairment of spontaneous alternation behavior in the Y-maze task might be mediated mainly by NOergic activation via the nAChR-related pathway.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalNeuroscience Letters
Volume462
Issue number3
DOIs
Publication statusPublished - Sep 25 2009

Keywords

  • Acetylcholine
  • Galantamine
  • Nitric oxide
  • Working memory
  • l-NAME

ASJC Scopus subject areas

  • Neuroscience(all)

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    Tanaka, K. I., Yagi, T., Shimakoshi, R., Azuma, K., Nanba, T., Ogo, H., Tamura, A., & Asanuma, M. (2009). Effects of galantamine on l-NAME-induced behavioral impairment in Y-maze task in mice. Neuroscience Letters, 462(3), 235-238. https://doi.org/10.1016/j.neulet.2009.07.024