Effects of gaba on neurons of the gustatory and visceral zones of the parabrachial nucleus in rats

Motoi Kobashi, Robert M. Bradley

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Response characteristics of neurons in the gustatory and visceral zone of the parabrachial nucleus (PBN) to γ-aminobutyric acid (GABA) were examined using whole cell recordings in slices of the rat. Based on the recording site, neurons were divided into three groups: neurons in the dorsolateral quadrant of the PBN (DL-neurons), neurons in the dorsomedial quadrant of the PBN (DM-neurons) and neurons in the ventromedial quadrant of the PBN (VM-neurons). Recordings were made from 44 DL-, 43 DM-, 39 VM- neurons. Superfusion of GABA resulted in a concentration, dependent reduction in input resistance in 67.5% of the neurons in the PBN (73.1% of the DL-, 62.5% of the DM-, 66.7% of the VM-neurons). No obvious difference of the concentration-response curve was found among three groups. The mean reversal potential of the GABA effect was about -74 mV and no significant differences were observed among three groups of neurons. The GABA response was partly or completely blocked by the GABA(A) antagonist bicuculline in all neurons tested. Superfusion of the GABA(A) agonist muscimol resulted in a decrease of the input resistance in all neurons tested. It was concluded that GABA functions as an inhibitory neurotransmitter in both gustatory and visceral part of the PBN, mediated in part, by GABA(A) receptors.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalBrain Research
Volume799
Issue number2
DOIs
Publication statusPublished - Jul 20 1998

Keywords

  • Inhibition
  • Parabrachial nucleus
  • Sensory processing
  • Slice
  • Synaptic processing

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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