Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain

Masahiro Nishibori; Ryozo Oishi; Yoshinori Itoh; Kiyomi Saeki

doi:10.1254/jjp.41.403

Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain

Masahiro Nishibori, Ryozo Oishi, Yoshinori Itoh, Kiyomi Saeki

Research output: Contribution to journal › Article

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Abstract

The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5–15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5–15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by α-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.

Original language	English
Pages (from-to)	403-408
Number of pages	6
Journal	The Japanese Journal of Pharmacology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1254/jjp.41.403
Publication status	Published - Jan 1 1986

ASJC Scopus subject areas

Pharmacology

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abstract = "The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5–15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5–15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by α-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.",

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