Effects of Fujibitol, a remedy for nasal symptoms, on experimental allergic rhinitis in rats

M. Kakimoto, Y. Sugimoto, M. Harada, Y. Kobayashi, C. Okuma, C. Taga, C. Kamei

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, i.e. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity induced by antigen was also inhibited by Fujibitol. On the other hand, no inhibitory effects were observed on either the nasal allergic symptoms or increase in dye leakage into the nasal cavity induced by histamine. However, Fujibitol was effective in inhibiting histamine release from the nasal cavity induced by antigen. Oxatomide used as positive control drug showed potent inhibitory effects on nasal symptoms and dye leakage into the nasal cavity induced by histamine and antigen. These results suggested that Fujibitol showed a remarkable protective effect against experimental rhinitis induced by antigen via inhibition of histamine release from the nasal cavity.

Original languageEnglish
Pages (from-to)1055-1058
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume23
Issue number9
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Allergic rhinitis
  • Fujibitol
  • Increase in dye leakage
  • Nasal symptoms

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Effects of Fujibitol, a remedy for nasal symptoms, on experimental allergic rhinitis in rats'. Together they form a unique fingerprint.

  • Cite this