Effects of fluoride release from bis-GMA/TEGDMA resin regulated by γ-methacryloxypropyltrimethoxysilane on demineralization of bovine enamel

Satoshi Nakabo, Yasuhiro Torii, Toshiyuki Itota, Kunio Ishikawa, Koji Miyazaki, Kazuomi Suzuki, Masahiro Yoshiyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We previously demonstrated that fluoride release from resins could be regulated by the polysiloxane coating of the fluoride additives. The present study investigated the effects of regulated fluoride release from resin on enamel demineralization in vitro. Bovine enamel cavities were restored with bis-GMA/TEGDMA resins containing 50 wt% NaF powders treated with or without γ-methacryloxypropyltrimethoxysilane. Specimens were immersed in distilled water that was changed daily to measure the amount of fluoride released over 40 days, and thereafter subjected to pH-cycling. Microradiographic observations were performed to determine total mineral loss (ΔZ) and lesion depth (Ld) on the enamel. In addition, fluorine distribution was analyzed using EPMA. The resin containing untreated NaF exhibited high-rate and short-term fluoride release, whereas the resin containing treated NaF released low concentrations of fluoride over a longer period. The former showed high fluorine uptake in the adjacent enamel. In contrast, the latter showed high fluorine uptake not only in the adjacent enamel, but also in a wider area of enamel surface. The latter also showed lower ΔZ and Ld values in the surrounding enamel, indicating a high inhibitory effect on caries formation. Therefore, it is suggested that regulated fluoride release from the resin based on polysiloxane coating is effective in preventing caries formation.

Original languageEnglish
Pages (from-to)3503-3508
Number of pages6
JournalBiomaterials
Volume23
Issue number16
DOIs
Publication statusPublished - 2002

Keywords

  • Demineralization
  • Enamel
  • Fluoride release
  • Polysiloxane
  • Regulation
  • Resin

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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