Abstract
The relationship between exercise training and nitric oxide-related parameters was examined in a cross-sectional study and an intervention study. A cross-sectional study using 184 employees was conducted to observe the association of exercise habits with serum arginase (ELISA and activity), L-arginine, L-citrulline, L-ornithine, NOx, exhaled nitric oxide, blood pressure, FEV1%, hs-CRP, HDL-cholesterol, IgE, and life style factors. An intervention study was also conducted to evaluate the changes of serum arginase I, nitric oxide-related parameters, and mRNA levels of anti-oxidant enzymes in blood monocytes before and after 1 h of aerobic exercise training per day for a month. Exercise habits were associated with increased arginase activity and a moderate alcohol drinking habit, after adjustment with several covariates. Aerobic exercise training induced a decrease in L-arginine and diastolic blood pressure and induced an increase in NO2- and urea. Moreover, mRNA expression of anti-oxidant enzymes, such as catalase and GPX1, and a life elongation enzyme, SIRT3, were significantly increased after aerobic exercise. The results that aerobic exercise training increased NO generation, reduced blood pressure, and induced anti-oxidant enzymes via SIRT3 suggest that exercise training may be an important factor for the prevention of disease by inducing intrinsic NO and anti-oxidant enzymes.
| Original language | English |
|---|---|
| Pages (from-to) | 180-186 |
| Number of pages | 7 |
| Journal | Journal of Clinical Biochemistry and Nutrition |
| Volume | 60 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1 2017 |
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Keywords
- Blood pressure
- Exercise
- Intervention research
- L-arginine
- Nitric oxide
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Clinical Biochemistry
Cite this
Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes. / Tsukiyama, Yorika; Ito, Tatsuo; Nagaoka, Kenjiro; Eguchi, Eri; Ogino, Keiki.
In: Journal of Clinical Biochemistry and Nutrition, Vol. 60, No. 3, 01.05.2017, p. 180-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes
AU - Tsukiyama, Yorika
AU - Ito, Tatsuo
AU - Nagaoka, Kenjiro
AU - Eguchi, Eri
AU - Ogino, Keiki
PY - 2017/5/1
Y1 - 2017/5/1
N2 - The relationship between exercise training and nitric oxide-related parameters was examined in a cross-sectional study and an intervention study. A cross-sectional study using 184 employees was conducted to observe the association of exercise habits with serum arginase (ELISA and activity), L-arginine, L-citrulline, L-ornithine, NOx, exhaled nitric oxide, blood pressure, FEV1%, hs-CRP, HDL-cholesterol, IgE, and life style factors. An intervention study was also conducted to evaluate the changes of serum arginase I, nitric oxide-related parameters, and mRNA levels of anti-oxidant enzymes in blood monocytes before and after 1 h of aerobic exercise training per day for a month. Exercise habits were associated with increased arginase activity and a moderate alcohol drinking habit, after adjustment with several covariates. Aerobic exercise training induced a decrease in L-arginine and diastolic blood pressure and induced an increase in NO2- and urea. Moreover, mRNA expression of anti-oxidant enzymes, such as catalase and GPX1, and a life elongation enzyme, SIRT3, were significantly increased after aerobic exercise. The results that aerobic exercise training increased NO generation, reduced blood pressure, and induced anti-oxidant enzymes via SIRT3 suggest that exercise training may be an important factor for the prevention of disease by inducing intrinsic NO and anti-oxidant enzymes.
AB - The relationship between exercise training and nitric oxide-related parameters was examined in a cross-sectional study and an intervention study. A cross-sectional study using 184 employees was conducted to observe the association of exercise habits with serum arginase (ELISA and activity), L-arginine, L-citrulline, L-ornithine, NOx, exhaled nitric oxide, blood pressure, FEV1%, hs-CRP, HDL-cholesterol, IgE, and life style factors. An intervention study was also conducted to evaluate the changes of serum arginase I, nitric oxide-related parameters, and mRNA levels of anti-oxidant enzymes in blood monocytes before and after 1 h of aerobic exercise training per day for a month. Exercise habits were associated with increased arginase activity and a moderate alcohol drinking habit, after adjustment with several covariates. Aerobic exercise training induced a decrease in L-arginine and diastolic blood pressure and induced an increase in NO2- and urea. Moreover, mRNA expression of anti-oxidant enzymes, such as catalase and GPX1, and a life elongation enzyme, SIRT3, were significantly increased after aerobic exercise. The results that aerobic exercise training increased NO generation, reduced blood pressure, and induced anti-oxidant enzymes via SIRT3 suggest that exercise training may be an important factor for the prevention of disease by inducing intrinsic NO and anti-oxidant enzymes.
KW - Blood pressure
KW - Exercise
KW - Intervention research
KW - L-arginine
KW - Nitric oxide
UR - http://www.scopus.com/inward/record.url?scp=85019737053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019737053&partnerID=8YFLogxK
U2 - 10.3164/jcbn.16-108
DO - 10.3164/jcbn.16-108
M3 - Article
AN - SCOPUS:85019737053
VL - 60
SP - 180
EP - 186
JO - Journal of Clinical Biochemistry and Nutrition
JF - Journal of Clinical Biochemistry and Nutrition
SN - 0912-0009
IS - 3
ER -