Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes

Yorika Tsukiyama, Tatsuo Ito, Kenjiro Nagaoka, Eri Eguchi, Keiki Ogino

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The relationship between exercise training and nitric oxide-related parameters was examined in a cross-sectional study and an intervention study. A cross-sectional study using 184 employees was conducted to observe the association of exercise habits with serum arginase (ELISA and activity), L-arginine, L-citrulline, L-ornithine, NOx, exhaled nitric oxide, blood pressure, FEV1%, hs-CRP, HDL-cholesterol, IgE, and life style factors. An intervention study was also conducted to evaluate the changes of serum arginase I, nitric oxide-related parameters, and mRNA levels of anti-oxidant enzymes in blood monocytes before and after 1 h of aerobic exercise training per day for a month. Exercise habits were associated with increased arginase activity and a moderate alcohol drinking habit, after adjustment with several covariates. Aerobic exercise training induced a decrease in L-arginine and diastolic blood pressure and induced an increase in NO2- and urea. Moreover, mRNA expression of anti-oxidant enzymes, such as catalase and GPX1, and a life elongation enzyme, SIRT3, were significantly increased after aerobic exercise. The results that aerobic exercise training increased NO generation, reduced blood pressure, and induced anti-oxidant enzymes via SIRT3 suggest that exercise training may be an important factor for the prevention of disease by inducing intrinsic NO and anti-oxidant enzymes.

Original languageEnglish
Pages (from-to)180-186
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume60
Issue number3
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Blood pressure
Nitric Oxide
Oxidants
Arginase
Antioxidants
Exercise
Blood Pressure
Enzymes
Arginine
Habits
Citrulline
Messenger RNA
Ornithine
Catalase
Immunoglobulin E
HDL Cholesterol
Urea
Elongation
Cross-Sectional Studies
Blood

Keywords

  • Blood pressure
  • Exercise
  • Intervention research
  • L-arginine
  • Nitric oxide

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes. / Tsukiyama, Yorika; Ito, Tatsuo; Nagaoka, Kenjiro; Eguchi, Eri; Ogino, Keiki.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 60, No. 3, 01.05.2017, p. 180-186.

Research output: Contribution to journalArticle

Tsukiyama, Yorika ; Ito, Tatsuo ; Nagaoka, Kenjiro ; Eguchi, Eri ; Ogino, Keiki. / Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes. In: Journal of Clinical Biochemistry and Nutrition. 2017 ; Vol. 60, No. 3. pp. 180-186.
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