Effects of exercise training on nitric oxide, blood pressure and antioxidant enzymes

Yorika Tsukiyama, Tatsuo Ito, Kenjiro Nagaoka, Eri Eguchi, Keiki Ogino

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


The relationship between exercise training and nitric oxide-related parameters was examined in a cross-sectional study and an intervention study. A cross-sectional study using 184 employees was conducted to observe the association of exercise habits with serum arginase (ELISA and activity), L-arginine, L-citrulline, L-ornithine, NOx, exhaled nitric oxide, blood pressure, FEV1%, hs-CRP, HDL-cholesterol, IgE, and life style factors. An intervention study was also conducted to evaluate the changes of serum arginase I, nitric oxide-related parameters, and mRNA levels of anti-oxidant enzymes in blood monocytes before and after 1 h of aerobic exercise training per day for a month. Exercise habits were associated with increased arginase activity and a moderate alcohol drinking habit, after adjustment with several covariates. Aerobic exercise training induced a decrease in L-arginine and diastolic blood pressure and induced an increase in NO2- and urea. Moreover, mRNA expression of anti-oxidant enzymes, such as catalase and GPX1, and a life elongation enzyme, SIRT3, were significantly increased after aerobic exercise. The results that aerobic exercise training increased NO generation, reduced blood pressure, and induced anti-oxidant enzymes via SIRT3 suggest that exercise training may be an important factor for the prevention of disease by inducing intrinsic NO and anti-oxidant enzymes.

Original languageEnglish
Pages (from-to)180-186
Number of pages7
Journaljournal of clinical biochemistry and nutrition
Issue number3
Publication statusPublished - May 2017


  • Blood pressure
  • Exercise
  • Intervention research
  • L-arginine
  • Nitric oxide

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry


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