Effects of ethanol consumption on periodontal inflammation in rats

K. Irie, T. Tomofuji, N. Tamaki, T. Sanbe, D. Ekuni, T. Azuma, T. Maruyama, T. Yamamoto

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69 Citations (Scopus)

Abstract

Studies suggest a correlation between ethanol consumption and periodontal disease. We hypothesized that elevated levels of blood reactive oxygen species following ethanol consumption may increase inflammation in periodontal tissue. Rats were divided into 4 groups (6-7 rats/group). Two groups were fed an ethanol-containing liquid diet, and 2 groups were fed a pair-fed control diet. In one of each dietary group, periodontitis was ligature-induced, while the other group was left unligated. Chronic ethanol feeding alone decreased the ratio of reduced/oxidized glutathione and increased 8-hydroxydeoxy-guanosine and tumor necrosis factor (TNF)-α levels in the gingiva. Blood hydroperoxides were also increased. In ligature-induced periodontitis lesions, ethanol feeding enhanced polymorpho-nuclear leukocyte infiltration and TNF-α expression. The results suggest that chronic alcohol consumption increased periodontal inflammation, oxidative damage, and TNF-α production and had an additive effect on polymorphonuclear leukocyte infiltration and gingival oxidative damage, increasing the severity of periodontal inflammation in the ligature model.

Original languageEnglish
Pages (from-to)456-460
Number of pages5
JournalJournal of dental research
Volume87
Issue number5
DOIs
Publication statusPublished - May 1 2008

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Keywords

  • Animal studies
  • Ethanol
  • Oxidative stress
  • Periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

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