Effects of epidermal growth factor on ornithine decarboxylase activity and dna synthesis in rats during the perinatal period

Dan Yamamoto, Y. Hiramatsu, K. Eguchi, T. Kudo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of epidermal growth factor (EGF) on ornithine decarboxylase (ODC) activity and DNA synthesis were studied during the perinatal period in rats. EGF administration to neonatal rats increased ODC activity and DNA synthesis in neonatal rat liver, but not in brain. EGF administration to maternal rats increased ODC activity in maternal rat liver, but not in rat placenta and fetal rat liver. These data suggest that EGF has mitogenic effects on neonatal and maternal rat liver and play some important roles in fetal and neonatal growth.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalNeonatology
Volume63
Issue number5
DOIs
Publication statusPublished - Jan 1 1993

Keywords

  • DNA synthesis
  • Epidermal growth factor
  • Ornithine decarboxylase
  • Perinatal period
  • Rat

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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