Abstract
Epidermal growth factor (EGF) may play a key role in fetal growth. We have investigated the effects of EGF on glucose metabolism, the main source of energy during the early neonatal period. When compared to control, EGF treatment increased hepatic glycogen, plasma insulin, and the proportion of B cells in the islets of Langerhans, but decreased the concentration of plasma glucagon. Thus, the insulin-to-glucagon molar ratio in plasma was increased in the EGF-treated group. These data suggest that EGF shifts glucose metabolism from catabolism towards anabolism during the early neonatal period by controlling the pancreatic endocrine system. This effect may help the neonate in adapting to the extrauterine environment after birth.
| Original language | English |
|---|---|
| Pages (from-to) | 26-32 |
| Number of pages | 7 |
| Journal | Biology of the Neonate |
| Volume | 68 |
| Issue number | 1 |
| Publication status | Published - 1995 |
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Keywords
- Epidermal growth factor
- Glucose metabolism
- Neonatal growth
- Pancreas
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health
Cite this
Effects of epidermal growth factor on glucose metabolism in neonatal rats. / Sato, Y.; Hiramatsu, Y.; Kudo, T.
In: Biology of the Neonate, Vol. 68, No. 1, 1995, p. 26-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of epidermal growth factor on glucose metabolism in neonatal rats
AU - Sato, Y.
AU - Hiramatsu, Y.
AU - Kudo, T.
PY - 1995
Y1 - 1995
N2 - Epidermal growth factor (EGF) may play a key role in fetal growth. We have investigated the effects of EGF on glucose metabolism, the main source of energy during the early neonatal period. When compared to control, EGF treatment increased hepatic glycogen, plasma insulin, and the proportion of B cells in the islets of Langerhans, but decreased the concentration of plasma glucagon. Thus, the insulin-to-glucagon molar ratio in plasma was increased in the EGF-treated group. These data suggest that EGF shifts glucose metabolism from catabolism towards anabolism during the early neonatal period by controlling the pancreatic endocrine system. This effect may help the neonate in adapting to the extrauterine environment after birth.
AB - Epidermal growth factor (EGF) may play a key role in fetal growth. We have investigated the effects of EGF on glucose metabolism, the main source of energy during the early neonatal period. When compared to control, EGF treatment increased hepatic glycogen, plasma insulin, and the proportion of B cells in the islets of Langerhans, but decreased the concentration of plasma glucagon. Thus, the insulin-to-glucagon molar ratio in plasma was increased in the EGF-treated group. These data suggest that EGF shifts glucose metabolism from catabolism towards anabolism during the early neonatal period by controlling the pancreatic endocrine system. This effect may help the neonate in adapting to the extrauterine environment after birth.
KW - Epidermal growth factor
KW - Glucose metabolism
KW - Neonatal growth
KW - Pancreas
UR - http://www.scopus.com/inward/record.url?scp=0029131369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029131369&partnerID=8YFLogxK
M3 - Article
C2 - 7578634
AN - SCOPUS:0029131369
VL - 68
SP - 26
EP - 32
JO - Neonatology
JF - Neonatology
SN - 1661-7800
IS - 1
ER -