Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

Kozo Yamaji, Masamitsu Kawanami, Atsushi Matsumoto, Tomoomi Odajima, Yoshihiro Nishitani, Kensuke Iwasaka, Keiko Yoshimitsu, Masahiro Yoshiyama

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalDental materials journal
Volume26
Issue number4
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Aging
  • Bone formation
  • Dose of rhBMP-2

ASJC Scopus subject areas

  • Ceramics and Composites
  • Dentistry(all)

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