Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

Kozo Yamaji, Masamitsu Kawanami, Atsushi Matsumoto, Tomoomi Odajima, Yoshihiro Nishitani, Kensuke Iwasaka, Keiko Yoshimitsu, Masahiro Yoshiyama

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 μg to 4 μg, and decreased significantly as the dosage increased from 8 μg to 24 μg. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 μg to 16 μg, and did not significantly change as the dosage increased from 16 μg to 24 μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalDental Materials Journal
Volume26
Issue number4
Publication statusPublished - Jul 2007

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Osteogenesis
Rats
Bone
Bone and Bones
Porifera
Copolymers

Keywords

  • Aging
  • Bone formation
  • Dose of rhBMP-2

ASJC Scopus subject areas

  • Dentistry(all)
  • Biomaterials

Cite this

Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats. / Yamaji, Kozo; Kawanami, Masamitsu; Matsumoto, Atsushi; Odajima, Tomoomi; Nishitani, Yoshihiro; Iwasaka, Kensuke; Yoshimitsu, Keiko; Yoshiyama, Masahiro.

In: Dental Materials Journal, Vol. 26, No. 4, 07.2007, p. 481-486.

Research output: Contribution to journalArticle

Yamaji, K, Kawanami, M, Matsumoto, A, Odajima, T, Nishitani, Y, Iwasaka, K, Yoshimitsu, K & Yoshiyama, M 2007, 'Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats', Dental Materials Journal, vol. 26, no. 4, pp. 481-486.
Yamaji K, Kawanami M, Matsumoto A, Odajima T, Nishitani Y, Iwasaka K et al. Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats. Dental Materials Journal. 2007 Jul;26(4):481-486.
Yamaji, Kozo ; Kawanami, Masamitsu ; Matsumoto, Atsushi ; Odajima, Tomoomi ; Nishitani, Yoshihiro ; Iwasaka, Kensuke ; Yoshimitsu, Keiko ; Yoshiyama, Masahiro. / Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats. In: Dental Materials Journal. 2007 ; Vol. 26, No. 4. pp. 481-486.
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