Effects of dietary supplementation with N-3 fatty acids compared with N- 6 fatty acids on bronchial asthma

M. Okamoto, Fumihiro Mitsunobu, Kozo Ashida, T. Mifune, Y. Hosaki, H. Tsugeno, S. Harada, Y. Tanizaki

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Objective: The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes. Methods and Subjects: 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups. Results: The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p1.0 (p25 (p1.0 (p

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalInternal Medicine
Volume39
Issue number2
Publication statusPublished - 2000

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Omega-6 Fatty Acids
Leukotriene B4
Omega-3 Fatty Acids
Dietary Supplements
Corn Oil
Asthma
Leukotriene C4
Leukocytes
Fatty Acids
Lung
perilla seed oil

Keywords

  • α-linolenic acid
  • Leukotriene B4
  • Leukotriene C4
  • Perilla seed oil
  • Respiratory function

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Effects of dietary supplementation with N-3 fatty acids compared with N- 6 fatty acids on bronchial asthma. / Okamoto, M.; Mitsunobu, Fumihiro; Ashida, Kozo; Mifune, T.; Hosaki, Y.; Tsugeno, H.; Harada, S.; Tanizaki, Y.

In: Internal Medicine, Vol. 39, No. 2, 2000, p. 107-111.

Research output: Contribution to journalArticle

Okamoto, M, Mitsunobu, F, Ashida, K, Mifune, T, Hosaki, Y, Tsugeno, H, Harada, S & Tanizaki, Y 2000, 'Effects of dietary supplementation with N-3 fatty acids compared with N- 6 fatty acids on bronchial asthma', Internal Medicine, vol. 39, no. 2, pp. 107-111.
Okamoto, M. ; Mitsunobu, Fumihiro ; Ashida, Kozo ; Mifune, T. ; Hosaki, Y. ; Tsugeno, H. ; Harada, S. ; Tanizaki, Y. / Effects of dietary supplementation with N-3 fatty acids compared with N- 6 fatty acids on bronchial asthma. In: Internal Medicine. 2000 ; Vol. 39, No. 2. pp. 107-111.
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AU - Okamoto, M.

AU - Mitsunobu, Fumihiro

AU - Ashida, Kozo

AU - Mifune, T.

AU - Hosaki, Y.

AU - Tsugeno, H.

AU - Harada, S.

AU - Tanizaki, Y.

PY - 2000

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AB - Objective: The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes. Methods and Subjects: 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups. Results: The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p1.0 (p25 (p1.0 (p

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