Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma

Makoto Okamoto, Fumihiro Mitsunobu, Kozo Ashida, Takashi Mifune, Yasuhiro Hosaki, Hirofumi Tsugeno, Seishi Harada, Yoshiro Tanizaki

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objective The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes. Methods and Subjects 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups. Results The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p<0.05) and LTC4 at 2 weeks (p<0.05) after dietary supplementation. Significant increases in the value of PEF (p<0.05), FVC (p<0.01), FEV1.0 (p<0.05) and V̇25 (p<0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p<0.05) and FEV1.0 (p<0.05) were observed between the two groups after 4 weeks of dietary supplementation. Conclusion These results suggest that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalInternal Medicine
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2000

Keywords

  • Leukotriene B4
  • Leukotriene C4
  • Perilla seed oil
  • Respiratory function
  • α-linolenic acid

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma'. Together they form a unique fingerprint.

  • Cite this