Effects of corticosterone on 5-HT(1A) and 5-HT2 receptor binding and on the receptor-mediated behavioral responses of rats

Katsuyuki Takao, Tadashi Nagatani, Yoshihisa Kitamura, Shigeto Yamawaki

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68 Citations (Scopus)

Abstract

The effects of corticosterone after binding to 5-HT(1A) and 5-HT2 receptors were studied in rats. Binding of [3H]8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) to 5-HT(1A) receptors in the hippocampus decreased 24 h after both acute and chronic (14 day) administration of CORT (50 mg/kg, s.c.). Chronic, but not acute, CORT treatment increased [3H]ketanserin binding to 5-HT2 receptors in the frontal cortex. Receptor-mediated behavioral responses were also examined following acute and chronic CORT treatment. Flat body posture and hypothermia induced by 8-OH-DPAT, a 5-HT(1A) receptor agonist, were attenuated following chronic, but not acute, CORT administration. (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), a 5-HT2 receptor agonist, induced wet-dog shakes, but not hyperthermia and this response was increased 24 h after the chronic administration of CORT, These findings indicate that both 5-HT(1A) and 5-HT2 receptor functions were changed following chronic exposure to high levels of CORT. Such changes in these receptor systems may play an important role in the etiology of affective disorders.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalEuropean Journal of Pharmacology
Volume333
Issue number2-3
DOIs
Publication statusPublished - Aug 27 1997
Externally publishedYes

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Keywords

  • 5-HT (5-hydroxytryptamine, serotonin) syndrome
  • 5-HT(1A) receptor
  • 5-HT receptor
  • Body temperature
  • Corticosterone
  • Wet-dog shake

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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