Effects of coffee intake on oxidative stress during aging-related alterations in periodontal tissue

Terumasa Kobayashi, Takayuki Maruyama, Toshiki Yoneda, Hisataka Miyai, Tetsuji Azuma, Takaaki Tomofuji, Daisuke Ekuni, Manabu Morita

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. Materials and Methods: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. Results: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. Conclusion: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway.

Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalIn Vivo
Volume34
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Aging
  • Antioxidant
  • Coffee
  • Oxidative stress
  • Periodontal tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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