Effects of chronic codergocrine mesylate administration on the brain somatostatinergic system in aged rats

Ken ichi Tanaka, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Hsi hsien Chou, Akitane Mori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Codergocrine mesylate (dihydroergotoxine; DHET), which is an ergot derivative, has been reported to counteract some age-induced impairments in brain function, but the mechanism of these effects is not known. We examined the effect of chronic DHET administration on the somatostatinergic system in the brains of aged rats. Intraperitoneal injections of DHET (1 mg/kg per day) or of vehicle were given to aged rats for 14 days, and resulted in a significant increase in somatostatin (SOM) receptor binding in all six brain regions examined except the hindbrain. DHET had no effect on SOM receptor binding in the brains of young-adult rats. However, the SOM concentration in aged rats was nearly identical to that in young-adult rats and the SOM concentration in different brain areas did not change after chronic administration of DHET. Thus, the present results suggest that chronic administration of DHET can ameliorate at least one of the age-induced impairments of brain somatostatinergic function.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume15
Issue number2
DOIs
Publication statusPublished - Jan 1 1992

Keywords

  • Aged-rat brain
  • Codergocrine mesylate (dihydroergotoxine)
  • Receptors
  • Somatostatin

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Effects of chronic codergocrine mesylate administration on the brain somatostatinergic system in aged rats'. Together they form a unique fingerprint.

  • Cite this