Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-d-aspartate in the aged-rat brain

Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Masato Asanuma, Akitane Mori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We assayed N-methyl-d-aspartate (NMDA) receptors [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) bindings) and evaluated their distribution in the brain by quantitative autoradiography in young adult and aged rats. In the young adult rats, NMDA receptors were present at relatively high concentrations in the cerebral cortex and hippocampus. In the aged rats, NMDA receptors were decreased in the nealy all areas of the brain, especially in the cerebral cortex and hippocampus. Chronic administration of bifemelane hydrochloride, a drug for sequela of cerebrovascular diseased, at a dose of 15 mg/kg/day for 14 days, markedly attenuated these decrease in NMDA receptors. Since NMDA receptors are considered to be involved in memory and learning processes, our results suggest that bifemelane hydrochloride may be applicable to the treatment of disturbed memory and learning.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalNeurochemical Research
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 1992

Fingerprint

Aspartic Acid
Rats
Brain
Cerebral Cortex
Young Adult
Hippocampus
Learning
Cerebrovascular Disorders
Data storage equipment
Autoradiography
aspartic acid receptor
bifemelane
Pharmaceutical Preparations
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
Therapeutics

Keywords

  • aged-rat brain
  • autoradiography
  • bifemelane hydrochloride
  • NMDA receptors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-d-aspartate in the aged-rat brain. / Ogawa, Norio; Mizukawa, Kiminao; Haba, Kumiko; Asanuma, Masato; Mori, Akitane.

In: Neurochemical Research, Vol. 17, No. 7, 07.1992, p. 687-691.

Research output: Contribution to journalArticle

Ogawa, Norio ; Mizukawa, Kiminao ; Haba, Kumiko ; Asanuma, Masato ; Mori, Akitane. / Effects of chronic bifemelane hydrochloride administration on receptors for N-methyl-d-aspartate in the aged-rat brain. In: Neurochemical Research. 1992 ; Vol. 17, No. 7. pp. 687-691.
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