Effects of chlorogenic acid and its metabolites on the sleep-wakefulness cycle in rats

Kazuaki Shinomiya, Junji Omichi, Ryoko Ohnishi, Hideyuki Ito, Takashi Yoshida, Chiaki Kamei

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effect of chlorogenic acid on the sleep-wakefulness cycle in rats was investigated in comparison with those of caffeic acid (the metabolite of chlorogenic acid) and dihydrocaffeic acid (the metabolite of caffeic acid). A significant prolongation of sleep latency was observed with chlorogenic acid and caffeic acid at a dose of 500 and 200 mg/kg, respectively. On the other hand, no remarkable effects were observed with dihydrocaffeic acid even at a dose of 500 mg/kg. Caffeine caused a significant increase in sleep latency and waking time and decrease in non-rapid eye movement sleep time at a dose of 10 mg/kg. In contrast, chlorogenic acid and its metabolites had no significant effects on each sleep state. From these results, it may be concluded that chrologenic acid caused a mild arousal effect compared with that of caffeine, and the effect of chlorogenic acid may have occurred through its metabolite caffeic acid.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalEuropean Journal of Pharmacology
Volume504
Issue number3
DOIs
Publication statusPublished - Nov 19 2004

Keywords

  • Arousal effect
  • Caffeic acid
  • Caffeine
  • Chlorogenic acid
  • Dihydrocaffeic acid
  • Sleep latency

ASJC Scopus subject areas

  • Pharmacology

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