Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice

Ryoko Ohnishi, Hideyuki Ito, Ayumu Iguchi, Kazuaki Shinomiya, Chiaki Kamei, Tsutomu Hatano, Takashi Yoshida

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20 Citations (Scopus)


Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity.

Original languageEnglish
Pages (from-to)2560-2563
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number10
Publication statusPublished - Nov 6 2006



  • Caffeic acid
  • Chlorogenic acid
  • Microbial metabolite
  • Psychostimulant activity
  • Spontaneous locomotor activity

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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