Effects of certain resorcinol derivatives on the tyrosinase activity and the growth of melanoma cells

Kenji Tasaka, Chiaki Kamei, Shinji Nakano, Yasuo Takeuchi, Masatoshi Yamato

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Effects of certain resorcinol derivatives on tyrosinase activity, melanin formation and some other biological activities were studied in order to develop a new, potent depigmentor and/or antimelanoma drug. NKO-09, having isopentyl group in position 6 of resorcinol, exhibited a more potent effect than the compounds which have methyl (NKO-10), ethyl (NKO-11), hexyl (KOM- 14), octyl (NKO-14), decyl (NKO-19), dodecyl (NKO-15) and tetradecyl (NKO- 16) group in inhibiting the tyrosinase activities (both tyrosine hydroxylation and dopa oxidation). NKO-09 was more potent than hydroquinone in inhibiting the tyrosine hydroxylation; furthermore, NKO-09 inhibited the dopa oxidation different from hydroquinone. In the studies on melanin formation, protein synthesis and the growth of the melanoma cells, NKO-09 caused the most potent effect among the test compounds, except for the growth of the melanoma cells. KOM-14 was more potent than NKO-09 in the antimelanoma activity, and its effect was superior than that of 5-fluorouracil. From these findings, it is suggested that NKO-09 and KOM-14 can be used as an efficacious depigmentor and antimelanoma drug, respectively.

Original languageEnglish
Pages (from-to)99-109
Number of pages11
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume20
Issue number2
DOIs
Publication statusPublished - Mar 1 1998

Keywords

  • 5- Fluorouracil
  • Hydroquinone
  • Melanoma cells
  • Resorcinol derivatives
  • Tyrosinase activity

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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