TY - JOUR
T1 - Effects of cardiac sympathetic innervation on regional wall motion abnormality in patients with long QT syndrome
AU - Yamanari, H.
AU - Nakayama, K.
AU - Morita, H.
AU - Miyazi, K.
AU - Fukushima, K.
AU - Matsubara, H.
AU - Emori, T.
AU - Ohe, T.
PY - 2000
Y1 - 2000
N2 - Aim - To assess the spatial relation between regional cardiac sympathetic innervation and regional ventricular repolarisation indicated by ventricular wall motion abnormality in patients with congenital long QT syndrome. Design - Regional percentage uptake and washout rate of 123I metaiodobenzylguanidine (MIBG) were measured to assess cardiac sympathetic innervation in septum, anterior wall, lateral wall, and posterior wall. Left ventricular short axis images on echocardiography were digitised to reconstruct digitised M mode echocardiograms, from which left ventricular wall thickness curves were obtained. The wall thickening time (ThT) was defined as the period in which the instantaneous wall thickness exceeded 90% of the maximum wall thickness. The ThT was measured from the ventricular wall thickness curve at the same segments where regional percentage uptake and washout rate of 123I MIBG were measured. Patients - Seven patients with long QT syndrome. Results - The regional washout rate (mean (SD)) of 123I MIBG in patients with long QT syndrome was greater in the segments with decreased percentage uptake of 123I MIBG than in those without (17.4 (10.6)% v 9.7 (16.5)%, p < 0.03). ThT in segments both with and without decreased percentage uptake of 123I MIBG was longer than in control subjects (p < 0.0001). ThT was longer in the segments with decreased percentage uptake of 123I MIBG than in those without (199 (70) ms v 150 (66) ms, p = 0.0018). Conclusions - Activation of regional cardiac sympathetic terminals is likely to participate in additional regional prolongation of ventricular repolarisation in patients with long QT syndrome.
AB - Aim - To assess the spatial relation between regional cardiac sympathetic innervation and regional ventricular repolarisation indicated by ventricular wall motion abnormality in patients with congenital long QT syndrome. Design - Regional percentage uptake and washout rate of 123I metaiodobenzylguanidine (MIBG) were measured to assess cardiac sympathetic innervation in septum, anterior wall, lateral wall, and posterior wall. Left ventricular short axis images on echocardiography were digitised to reconstruct digitised M mode echocardiograms, from which left ventricular wall thickness curves were obtained. The wall thickening time (ThT) was defined as the period in which the instantaneous wall thickness exceeded 90% of the maximum wall thickness. The ThT was measured from the ventricular wall thickness curve at the same segments where regional percentage uptake and washout rate of 123I MIBG were measured. Patients - Seven patients with long QT syndrome. Results - The regional washout rate (mean (SD)) of 123I MIBG in patients with long QT syndrome was greater in the segments with decreased percentage uptake of 123I MIBG than in those without (17.4 (10.6)% v 9.7 (16.5)%, p < 0.03). ThT in segments both with and without decreased percentage uptake of 123I MIBG was longer than in control subjects (p < 0.0001). ThT was longer in the segments with decreased percentage uptake of 123I MIBG than in those without (199 (70) ms v 150 (66) ms, p = 0.0018). Conclusions - Activation of regional cardiac sympathetic terminals is likely to participate in additional regional prolongation of ventricular repolarisation in patients with long QT syndrome.
KW - Long QT syndrome
KW - Regional wall motion
KW - Sympathetic innervation
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U2 - 10.1136/heart.83.3.295
DO - 10.1136/heart.83.3.295
M3 - Article
C2 - 10677409
AN - SCOPUS:0034021626
VL - 83
SP - 295
EP - 300
JO - Heart
JF - Heart
SN - 1355-6037
IS - 3
ER -