Abstract
The dopamine reuptake inhibitor bupropion has clinically been proven to improve depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which bupropion acts in this model was explored specifically in relation to the site of action through the use of microinjections into the medial prefrontal cortex and nucleus accumbens. Bupropion significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by D2 and D3 receptor antagonists in normal rats. Furthermore, infusions of bupropion into the nucleus accumbens, but not medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Bupropion treatment plus repeated ACTH treatment significantly increased the extracellular dopamine concentration. These findings suggest the antidepressant-like effect of bupropion to be related to levels of dopamine in the rat nucleus accumbens.
| Original language | English |
|---|---|
| Pages (from-to) | 151-158 |
| Number of pages | 8 |
| Journal | Naunyn-Schmiedeberg's Archives of Pharmacology |
| Volume | 382 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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Keywords
- Bupropion
- Dopamine receptor
- Dopamine release
- Forced swim test
- Nucleus accumbens
- Treatment-resistant depression
ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats. / Kitamura, Yoshihisa; Yagi, Takahiko; Kitagawa, Kouhei; Shinomiya, Kazuaki; Kawasaki, Hiromu; Asanuma, Masato; Gomita, Yutaka.
In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 382, No. 2, 08.2010, p. 151-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats
AU - Kitamura, Yoshihisa
AU - Yagi, Takahiko
AU - Kitagawa, Kouhei
AU - Shinomiya, Kazuaki
AU - Kawasaki, Hiromu
AU - Asanuma, Masato
AU - Gomita, Yutaka
PY - 2010/8
Y1 - 2010/8
N2 - The dopamine reuptake inhibitor bupropion has clinically been proven to improve depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which bupropion acts in this model was explored specifically in relation to the site of action through the use of microinjections into the medial prefrontal cortex and nucleus accumbens. Bupropion significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by D2 and D3 receptor antagonists in normal rats. Furthermore, infusions of bupropion into the nucleus accumbens, but not medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Bupropion treatment plus repeated ACTH treatment significantly increased the extracellular dopamine concentration. These findings suggest the antidepressant-like effect of bupropion to be related to levels of dopamine in the rat nucleus accumbens.
AB - The dopamine reuptake inhibitor bupropion has clinically been proven to improve depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which bupropion acts in this model was explored specifically in relation to the site of action through the use of microinjections into the medial prefrontal cortex and nucleus accumbens. Bupropion significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by D2 and D3 receptor antagonists in normal rats. Furthermore, infusions of bupropion into the nucleus accumbens, but not medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Bupropion treatment plus repeated ACTH treatment significantly increased the extracellular dopamine concentration. These findings suggest the antidepressant-like effect of bupropion to be related to levels of dopamine in the rat nucleus accumbens.
KW - Bupropion
KW - Dopamine receptor
KW - Dopamine release
KW - Forced swim test
KW - Nucleus accumbens
KW - Treatment-resistant depression
UR - http://www.scopus.com/inward/record.url?scp=77955552059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955552059&partnerID=8YFLogxK
U2 - 10.1007/s00210-010-0521-x
DO - 10.1007/s00210-010-0521-x
M3 - Article
C2 - 20526847
AN - SCOPUS:77955552059
VL - 382
SP - 151
EP - 158
JO - Naunyn-Schmiedeberg's Archives of Pharmacology
JF - Naunyn-Schmiedeberg's Archives of Pharmacology
SN - 0028-1298
IS - 2
ER -