Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats

Yoshihisa Kitamura, Takahiko Yagi, Kouhei Kitagawa, Kazuaki Shinomiya, Hiromu Kawasaki, Masato Asanuma, Yutaka Gomita

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The dopamine reuptake inhibitor bupropion has clinically been proven to improve depression and treatment-resistant depression. We examined its influence on the duration of immobility during the forced swim test in adrenocorticotropic hormone (ACTH)-treated rats and further analyzed the possible role of dopamine receptors in this effect. Additionally, the mechanism by which bupropion acts in this model was explored specifically in relation to the site of action through the use of microinjections into the medial prefrontal cortex and nucleus accumbens. Bupropion significantly decreased the duration of immobility in normal and ACTH-treated rats. This effect was blocked by D2 and D3 receptor antagonists in normal rats. Furthermore, infusions of bupropion into the nucleus accumbens, but not medial prefrontal cortex, decreased the immobility of normal and ACTH-treated rats during the forced swim test. Bupropion treatment plus repeated ACTH treatment significantly increased the extracellular dopamine concentration. These findings suggest the antidepressant-like effect of bupropion to be related to levels of dopamine in the rat nucleus accumbens.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume382
Issue number2
DOIs
Publication statusPublished - Aug 1 2010

Keywords

  • Bupropion
  • Dopamine receptor
  • Dopamine release
  • Forced swim test
  • Nucleus accumbens
  • Treatment-resistant depression

ASJC Scopus subject areas

  • Pharmacology

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