Abstract
Bromocriptine, a dopamine agonist, alleviates symptoms of Parkinson's disease, even when administered alone, and is used for its treatment. Better therapeutic effects are, however, achieved when bromocriptine is used in combination with levodopa. In this study, we examined the biochemical changes caused by bromocriptine administration with and without levodopa, and evaluated the effects of the treatments on dopamine turnover in the mouse striatum. Results show that dopamine turnover is suppressed by the administration of bromocriptine alone with a slight decrease in the amount of dopamine, and dopamine turnover is very strongly promoted by the administration of levodopa. When the two drugs are administered together, bromocriptine enhances the levodopa-induced increase in dopamine turnover in the striatum. These findings indicate that bromocriptine therapy in combination with levodopa enhances the dopaminergic function and suggest that the combination therapy of bromocriptine and levodopa shows good efficacy. The results of this study may, thus, provide a theoretical basis for the combination therapy of bromocriptine and levodopa.
| Original language | English |
|---|---|
| Pages (from-to) | 271-277 |
| Number of pages | 7 |
| Journal | Journal of International Medical Research |
| Volume | 24 |
| Issue number | 3 |
| Publication status | Published - May 1996 |
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Keywords
- Bromocriptine
- Combination therapy
- Dopamine
- Dopamine turnover
- Levodopa
- Metabolite
ASJC Scopus subject areas
- Medicine(all)
Cite this
Effects of bromocriptine on dopamine turnover with or without levodopa. / Ogawa, N.; Asanuma, Masato; Tanaka, K.; Matsuura, K.; Iida, K.; Yamamoto, M.
In: Journal of International Medical Research, Vol. 24, No. 3, 05.1996, p. 271-277.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of bromocriptine on dopamine turnover with or without levodopa
AU - Ogawa, N.
AU - Asanuma, Masato
AU - Tanaka, K.
AU - Matsuura, K.
AU - Iida, K.
AU - Yamamoto, M.
PY - 1996/5
Y1 - 1996/5
N2 - Bromocriptine, a dopamine agonist, alleviates symptoms of Parkinson's disease, even when administered alone, and is used for its treatment. Better therapeutic effects are, however, achieved when bromocriptine is used in combination with levodopa. In this study, we examined the biochemical changes caused by bromocriptine administration with and without levodopa, and evaluated the effects of the treatments on dopamine turnover in the mouse striatum. Results show that dopamine turnover is suppressed by the administration of bromocriptine alone with a slight decrease in the amount of dopamine, and dopamine turnover is very strongly promoted by the administration of levodopa. When the two drugs are administered together, bromocriptine enhances the levodopa-induced increase in dopamine turnover in the striatum. These findings indicate that bromocriptine therapy in combination with levodopa enhances the dopaminergic function and suggest that the combination therapy of bromocriptine and levodopa shows good efficacy. The results of this study may, thus, provide a theoretical basis for the combination therapy of bromocriptine and levodopa.
AB - Bromocriptine, a dopamine agonist, alleviates symptoms of Parkinson's disease, even when administered alone, and is used for its treatment. Better therapeutic effects are, however, achieved when bromocriptine is used in combination with levodopa. In this study, we examined the biochemical changes caused by bromocriptine administration with and without levodopa, and evaluated the effects of the treatments on dopamine turnover in the mouse striatum. Results show that dopamine turnover is suppressed by the administration of bromocriptine alone with a slight decrease in the amount of dopamine, and dopamine turnover is very strongly promoted by the administration of levodopa. When the two drugs are administered together, bromocriptine enhances the levodopa-induced increase in dopamine turnover in the striatum. These findings indicate that bromocriptine therapy in combination with levodopa enhances the dopaminergic function and suggest that the combination therapy of bromocriptine and levodopa shows good efficacy. The results of this study may, thus, provide a theoretical basis for the combination therapy of bromocriptine and levodopa.
KW - Bromocriptine
KW - Combination therapy
KW - Dopamine
KW - Dopamine turnover
KW - Levodopa
KW - Metabolite
UR - http://www.scopus.com/inward/record.url?scp=0029903056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029903056&partnerID=8YFLogxK
M3 - Article
C2 - 8725988
AN - SCOPUS:0029903056
VL - 24
SP - 271
EP - 277
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 3
ER -