TY - JOUR
T1 - Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats
AU - Azuma, N.
AU - Sugimoto, Y.
AU - Mio, M.
AU - Shinomiya, Kazuaki
AU - Kamei, Chiaki
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.
AB - The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.
KW - Blood pressure
KW - Hippocampus
KW - Regional cerebral blood flow
KW - V antagonist
KW - V antagonist
KW - [Arg]-Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0038324165&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038324165&partnerID=8YFLogxK
U2 - 10.1358/mf.2003.25.3.769639
DO - 10.1358/mf.2003.25.3.769639
M3 - Article
C2 - 12743623
AN - SCOPUS:0038324165
SN - 0379-0355
VL - 25
SP - 193
EP - 197
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
IS - 3
ER -