Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats

N. Azuma, Y. Sugimoto, M. Mio, K. Shinomiya, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume25
Issue number3
DOIs
Publication statusPublished - Apr 1 2003

Keywords

  • Blood pressure
  • Hippocampus
  • Regional cerebral blood flow
  • V antagonist
  • V antagonist
  • [Arg]-Vasopressin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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