Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats

N. Azuma, Yukio Sugimoto, M. Mio, K. Shinomiya, Chiaki Kamei

Research output: Contribution to journalArticle

Abstract

The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume25
Issue number3
DOIs
Publication statusPublished - Apr 2003

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Inbred SHR Rats
Vasopressins
Hippocampus
OPC 21268
Subcutaneous Injections
Deamino Arginine Vasopressin
Blood Pressure

Keywords

  • [Arg]-Vasopressin
  • Blood pressure
  • Hippocampus
  • Regional cerebral blood flow
  • V antagonist
  • V antagonist

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats. / Azuma, N.; Sugimoto, Yukio; Mio, M.; Shinomiya, K.; Kamei, Chiaki.

In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 25, No. 3, 04.2003, p. 193-197.

Research output: Contribution to journalArticle

@article{44304b4cba26484196c302e1310a5f74,
title = "Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats",
abstract = "The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.",
keywords = "[Arg]-Vasopressin, Blood pressure, Hippocampus, Regional cerebral blood flow, V antagonist, V antagonist",
author = "N. Azuma and Yukio Sugimoto and M. Mio and K. Shinomiya and Chiaki Kamei",
year = "2003",
month = "4",
doi = "10.1358/mf.2003.25.3.769639",
language = "English",
volume = "25",
pages = "193--197",
journal = "Methods and Findings in Experimental and Clinical Pharmacology",
issn = "0379-0355",
publisher = "Prous Science",
number = "3",

}

TY - JOUR

T1 - Effects of [Arg8]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats

AU - Azuma, N.

AU - Sugimoto, Yukio

AU - Mio, M.

AU - Shinomiya, K.

AU - Kamei, Chiaki

PY - 2003/4

Y1 - 2003/4

N2 - The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.

AB - The effects of [Arg8]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocampus. The effects of the metabolic fragments AVP4-9 and AVP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site.

KW - [Arg]-Vasopressin

KW - Blood pressure

KW - Hippocampus

KW - Regional cerebral blood flow

KW - V antagonist

KW - V antagonist

UR - http://www.scopus.com/inward/record.url?scp=0038324165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038324165&partnerID=8YFLogxK

U2 - 10.1358/mf.2003.25.3.769639

DO - 10.1358/mf.2003.25.3.769639

M3 - Article

C2 - 12743623

AN - SCOPUS:0038324165

VL - 25

SP - 193

EP - 197

JO - Methods and Findings in Experimental and Clinical Pharmacology

JF - Methods and Findings in Experimental and Clinical Pharmacology

SN - 0379-0355

IS - 3

ER -