Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs

Yukio Sugimoto, Y. Nakayama, H. Kishida, T. Hayakawa, R. Fujiwara, C. Kamei

Research output: Contribution to journalArticle

Abstract

We examined the effects of platelet-activating factor (PAF) on β- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the β-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of β-adrenoceptors in guinea pigs lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of β-adrenoceptors. These findings suggest that apafant may be effective in nonspecific hyperreactivity in asthma.

Original languageEnglish
Pages (from-to)547-552
Number of pages6
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume19
Issue number8
Publication statusPublished - 1997

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WEB 2086
Platelet Activating Factor
Adrenergic Receptors
Guinea Pigs
Down-Regulation
Isoproterenol
Lung
Asthma

Keywords

  • β-Adrenoceptors
  • Apafant
  • Downregulation
  • PAF

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs. / Sugimoto, Yukio; Nakayama, Y.; Kishida, H.; Hayakawa, T.; Fujiwara, R.; Kamei, C.

In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 19, No. 8, 1997, p. 547-552.

Research output: Contribution to journalArticle

Sugimoto, Yukio ; Nakayama, Y. ; Kishida, H. ; Hayakawa, T. ; Fujiwara, R. ; Kamei, C. / Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs. In: Methods and Findings in Experimental and Clinical Pharmacology. 1997 ; Vol. 19, No. 8. pp. 547-552.
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