Abstract
We examined the effects of platelet-activating factor (PAF) on β- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the β-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of β-adrenoceptors in guinea pigs lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of β-adrenoceptors. These findings suggest that apafant may be effective in nonspecific hyperreactivity in asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 547-552 |
| Number of pages | 6 |
| Journal | Methods and Findings in Experimental and Clinical Pharmacology |
| Volume | 19 |
| Issue number | 8 |
| Publication status | Published - 1997 |
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Keywords
- β-Adrenoceptors
- Apafant
- Downregulation
- PAF
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs. / Sugimoto, Yukio; Nakayama, Y.; Kishida, H.; Hayakawa, T.; Fujiwara, R.; Kamei, C.
In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 19, No. 8, 1997, p. 547-552.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs
AU - Sugimoto, Yukio
AU - Nakayama, Y.
AU - Kishida, H.
AU - Hayakawa, T.
AU - Fujiwara, R.
AU - Kamei, C.
PY - 1997
Y1 - 1997
N2 - We examined the effects of platelet-activating factor (PAF) on β- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the β-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of β-adrenoceptors in guinea pigs lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of β-adrenoceptors. These findings suggest that apafant may be effective in nonspecific hyperreactivity in asthma.
AB - We examined the effects of platelet-activating factor (PAF) on β- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the β-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of β-adrenoceptors in guinea pigs lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of β-adrenoceptors. These findings suggest that apafant may be effective in nonspecific hyperreactivity in asthma.
KW - β-Adrenoceptors
KW - Apafant
KW - Downregulation
KW - PAF
UR - http://www.scopus.com/inward/record.url?scp=0031451792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031451792&partnerID=8YFLogxK
M3 - Article
C2 - 9442478
AN - SCOPUS:0031451792
VL - 19
SP - 547
EP - 552
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology
SN - 0379-0355
IS - 8
ER -