Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs

Y. Sugimoto, Y. Nakayama, H. Kishida, T. Hayakawa, R. Fujiwara, C. Kamei

Research output: Contribution to journalArticlepeer-review


We examined the effects of platelet-activating factor (PAF) on β- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the β-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of β-adrenoceptors in guinea pigs lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of β-adrenoceptors. These findings suggest that apafant may be effective in nonspecific hyperreactivity in asthma.

Original languageEnglish
Pages (from-to)547-552
Number of pages6
JournalMethods and Findings in Experimental and Clinical Pharmacology
Issue number8
Publication statusPublished - Dec 1 1997


  • Apafant
  • Downregulation
  • PAF
  • β-Adrenoceptors

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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