Abstract
We examined the effects of platelet-activating factor (PAF) on β- adrenoceptors and the functional response to isoproterenol in guinea pig parenchymal strips. PAF caused a reduction in the relaxation of guinea pig lung parenchymal strips induced by the β-adrenoceptor agonist, isoproterenol. In addition, PAF decreased the density of β-adrenoceptors in guinea pigs lung without any change in the affinity. Apafant, a potent PAF antagonist, inhibited the above changes, indicating that it inhibited the downregulation of β-adrenoceptors. These findings suggest that apafant may be effective in nonspecific hyperreactivity in asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 547-552 |
| Number of pages | 6 |
| Journal | Methods and Findings in Experimental and Clinical Pharmacology |
| Volume | 19 |
| Issue number | 8 |
| Publication status | Published - Dec 1 1997 |
Keywords
- Apafant
- Downregulation
- PAF
- β-Adrenoceptors
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
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Sugimoto, Y., Nakayama, Y., Kishida, H., Hayakawa, T., Fujiwara, R., & Kamei, C. (1997). Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs. Methods and Findings in Experimental and Clinical Pharmacology, 19(8), 547-552.