Effects of antiallergic drugs on histamine release from rat peritoneal mast cells induced by bradykinin

Y. Sugimoto, T. Tarumi, Q. E. Zhao, Y. Fujii, C. Kamei

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Effects of antiallergic drugs on bradykinin-induced histamine release and intracellular Ca2+ release from peritoneal mast cells were studied in rats. Bradykinin caused a concentration-dependent histamine release as well as Ca2+ release from the intracellular Ca store of peritoneal mast cells. Antiallergic drugs used in this study showed an inhibition of not only histamine release but also Ca2+ release. The Ca2+ release from the intracellular Ca store induced by bradykinin was more sensitive to antiallergic drugs than histamine release from mast cells. Mequitazine and terfenadine caused potent inhibitory effects on both responses, whereas effects of ketotifen and cromolyn sodium were relatively weak. In conclusion, histamine release from mast cells and intracellular C2+ release induced by bradykinin were inhibited by antiallergic drugs similar to those induced by substance P and compound 48/80.

Original languageEnglish
Pages (from-to)457-462
Number of pages6
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume20
Issue number6
DOIs
Publication statusPublished - Jul 1 1998

Keywords

  • Antiallergic drug
  • Bradykinin
  • Histamine release
  • Mast cell
  • Rat

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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