Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral 6-hydroxydopamine lesions in rats

T. Hayakawa, Y. Sugimoto, Z. Chen, Y. Fujii, C. Kamei

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Abstract

1. Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral lesions of dopaminergic neurons were investigated in rats. 2. Dopaminergic neurons in rats were lesioned bilaterally by injection of 6-hydroxydopamine (6-OHDA; 8 μg) into the medial forebrain bundle at the level of the posterolateral hypothalamus. As a result, a decrease in locomotor activity and marked catalepsy and prolongation of grasping time were observed. 3. Levodopa, talipexole, bromocriptine and theophylline dose- dependently antagonized the decrease in locomotor activity induced by bilateral 6-OHDA lesions. These drugs also showed antagonistic effects on the appearance of catalepsy and prolongation of grasping time induced by bilateral 6-OHDA lesions. In contrast, trihexyphenidyl showed no antagonizing effect on the neurobehavioural changes induced by 6-OHDA lesions at any concentration tested. 4. Combined treatment with levodopa and talipexole antagonized the neurobehavioural changes induced by bilateral 6-OHDA lesions, whereas no marked changes were observed when either drug was administered separately. The same findings were noted with the simultaneous use of either levodopa (2 mg/kg) and theophylline (2 mg/kg) or talipexole (0.005 mg/kg) and theophylline (2 mg/kg). 5. These results indicate that this model may be useful for estimating the effects of drugs in the treatment of Parkinson's disease.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume26
Issue number5-6
DOIs
Publication statusPublished - Jul 13 1999

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Keywords

  • 6-hydroxydopamine
  • Bromocriptine
  • Levodopa
  • Neurobehavioural changes
  • Talipexole
  • Theophylline
  • Trihexyphenidyl

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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