Effects of anti-androgen treatment on the catecholamine synthetic pathway in the adrenal medulla of spontaneously hypertensive rats

Toshio Kumai, Masami Tanaka, Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Masako Asoh, Shinichi Kobayashi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We investigated the effects of the antiandrogen flutamide on the activity of tyrosine hydroxylase, the levels of its encoding mRNA, and catecholamine levels in the adrenal medulla of male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Flutamide (30 mg/kg) was administered subcutaneously daily (between 9 and 15 weeks of age). The systolic blood pressure of flutamide-treated SHR rats was lower than that of control SHR. Epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and the levels of encoding mRNA in the adrenal medulla were significantly lower in flutamide-treated SHR rats than in paired controls. Systolic blood pressure, epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and encoding mRNA in the adrenal medulla of WKY rats showed no significant differences between flutamide-treated and control groups. These findings suggested that flutamide may have cardiovascular effects through alteration of the catecholamine synthetic pathway caused by removal of androgen receptor stimulation on the expression of tyrosine hydroxylase in the adrenal medulla of male SHR rats.

Original languageEnglish
Pages (from-to)620-624
Number of pages5
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume357
Issue number6
DOIs
Publication statusPublished - Jul 16 1998
Externally publishedYes

Keywords

  • Adrenal medulla
  • Antiandrogen
  • Blood pressure
  • Catecholamine
  • SHR inbred
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Pharmacology

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