Effects of amiloride derivatives on the thermosensitivity of an adriamycin-resistant strain of Ehrlich ascites tumor cells

J. I. Asaumi, S. Kawasaki, K. Nishikawa, M. Kuroda, Y. Hiraki

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We investigated the effects of amiloride and its derivative MH-12-43 on the thermosensitivity of adriamycin-resistant cells. Effects of hyperthermia at 42°C were enhanced by 0.5 mM amiloride and 0.05 mM MH-12-43, which resulted in no decrease in survival rate by the treatment at 37°C for 120 min. Therefore, the combination of hyperthermia and amiloride derivatives was effective in the adriamycin-resistant cells as well as wild type cells. Further, since the survival rates by the treatment with 0.05 mM MH-12-43 were markedly lower than those with 0.5 mM amiloride from hyperthermia at 42°C, MH-12-43 might be more effective than amiloride.

Original languageEnglish
Pages (from-to)805-807
Number of pages3
JournalAnticancer research
Issue number3 A
Publication statusPublished - Jan 1 1994



  • Adriamycin-resistance
  • Amiloride
  • MH-12-43

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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