Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics

A. Kanehiro, K. Takahashi, R. Soda, M. Takata, K. Takeda, H. Sugano, K. Yamagata, Y. Katagi, I. Kimura

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Abstract

To clarify whether thromboxane A2 (TXA2) is involved in type III and IV allergy, or so called 'cell-mediated allergy', we studied the effect of a specific TXA2 synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics. The results revealed, firstly, that lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. Secondly, there was a tendency that neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood mononuclear cells stimulated by Candida antigen in intractable asthmatics were suppressed by OKY-046. Thirdly, leukotriene (LTC4) and superoxide (O2-) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. That is, OKY-046 has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils. These results suggest that TXA2 plays an important role in the development of bronchial asthma and OKY-046 might be a useful drug in the treatment of intractable asthmatics.

Original languageEnglish
Pages (from-to)584-594
Number of pages11
JournalJapanese Journal of Allergology
Volume41
Issue number5
Publication statusPublished - Jan 1 1992

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ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Kanehiro, A., Takahashi, K., Soda, R., Takata, M., Takeda, K., Sugano, H., Yamagata, K., Katagi, Y., & Kimura, I. (1992). Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics. Japanese Journal of Allergology, 41(5), 584-594.