Effects of a high-cholesterol diet on cell behavior in rat periodontitis

T. Tomofuji, H. Kusano, T. Azuma, Daisuke Ekuni, T. Yamamoto, T. Watanabe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Studies have shown an association between periodontitis and serum cholesterol levels. We hypothesized that high dietary cholesterol could influence periodontitis as a result of proliferation of the junctional epithelium. Rats were divided into 4 groups. Two groups were fed a regular diet, and 2 groups were fed a high-cholesterol diet. One of each dietary group was treated with periodontitis-inducing agents (lipopolysaccharide and proteases), while the other was treated with pyrogen-free water. Feeding rats with a high-cholesterol diet induced an increase in blood total cholesterol and a decrease in high-density lipoprotein cholesterol. Proliferation of the junctional epithelium with increasing bone resorption was promoted by the consumption of a high-cholesterol diet. High dietary cholesterol further increased the cell-proliferative activity of the junctional epithelium induced by lipopolysaccharide and proteases. These results suggest that high dietary cholesterol can initiate and augment periodontitis in the rat periodontitis model.

Original languageEnglish
Pages (from-to)752-756
Number of pages5
JournalJournal of Dental Research
Volume84
Issue number8
DOIs
Publication statusPublished - Aug 2005

Fingerprint

Periodontitis
Epithelial Attachment
Dietary Cholesterol
Cholesterol
Diet
Lipopolysaccharides
Peptide Hydrolases
Pyrogens
Bone Resorption
HDL Cholesterol
Water
Serum

Keywords

  • Apoptosis
  • Cell proliferation
  • Dietary cholesterol
  • Periodontitis
  • Serum lipids

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Effects of a high-cholesterol diet on cell behavior in rat periodontitis. / Tomofuji, T.; Kusano, H.; Azuma, T.; Ekuni, Daisuke; Yamamoto, T.; Watanabe, T.

In: Journal of Dental Research, Vol. 84, No. 8, 08.2005, p. 752-756.

Research output: Contribution to journalArticle

Tomofuji, T, Kusano, H, Azuma, T, Ekuni, D, Yamamoto, T & Watanabe, T 2005, 'Effects of a high-cholesterol diet on cell behavior in rat periodontitis', Journal of Dental Research, vol. 84, no. 8, pp. 752-756. https://doi.org/10.1177/154405910508400813
Tomofuji, T. ; Kusano, H. ; Azuma, T. ; Ekuni, Daisuke ; Yamamoto, T. ; Watanabe, T. / Effects of a high-cholesterol diet on cell behavior in rat periodontitis. In: Journal of Dental Research. 2005 ; Vol. 84, No. 8. pp. 752-756.
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