Effects of 2-substitution on 14-: Epi -19-nortachysterol-mediated biological events: Based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor

Daisuke Sawada, Shinji Kakuda, Akiko Takeuchi, Fumihiro Kawagoe, Midori Takimoto-Kamimura, Atsushi Kittaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Both 2α- and 2β-hydroxypropyl substituted 14-epi-1α,25-dihydroxy-19-nortachysterols were synthesized to study the human vitamin D receptor (hVDR) binding affinity, binding configurations, and interactions with amino acid residues in the ligand binding domain of hVDR by X-ray co-crystallographic analysis. In conjunction with our previous results on 14-epi-19-nortachysterol, 2-methylidene-, 2α-methyl-, 2β-methyl, and 2α-hydroxypropoxy-14-epi-19-nortachysterol, we propose a variety of effects of substitution at the C2 position in the 14-epi-19-nortachysterol skeleton on biological activities.

Original languageEnglish
Pages (from-to)2448-2455
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume16
Issue number14
DOIs
Publication statusPublished - Jan 1 2018

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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